Featured Research

from universities, journals, and other organizations

Higher BMI associated with lower mortality risk in patients with severe pulmonary hypertension

Date:
May 19, 2014
Source:
American Thoracic Society
Summary:
In patients with congestive heart failure, obesity and a larger waist size have paradoxically been associated with a better prognosis in the prior investigations. This effect, known as the obesity paradox phenomenon, is now being demonstrated in patients with severe pulmonary hypertension. "In our study of more than a thousand patients with significant pulmonary hypertension, we found that a higher body mass index (BMI) was associated with a reduced mortality risk, even after adjustment for baseline characteristics," stated a co-researcher.

In patients with congestive heart failure, obesity and a larger waist size have paradoxically been associated with a better prognosis in the prior investigations. This effect, known as the obesity paradox phenomenon, is now being demonstrated in patients with severe pulmonary hypertension.

"Obesity-related illnesses, particularly obesity hypoventilation syndrome and sleep apnea, may play a role in the development of pulmonary hypertension, and so we examined whether the protective effects of obesity seen in patients with heart failure were also seen in these patients," said researcher Jose Caceres, MD, of Jacobi Medical Center/Albert Einstein College of Medicine in the Bronx, NY. Pulmonary hypertension is high blood pressure in the arteries going to the lung.

"In our study of more than a thousand patients with significant pulmonary hypertension, we found that a higher body mass index (BMI) was associated with a reduced mortality risk, even after adjustment for baseline characteristics," stated co-researcher M. Khalid Mojadidi, MD.

The study was presented at the 2014 American Thoracic Society International Conference.

The study involved 1137 patients with significant pulmonary hypertension (pulmonary artery systolic pressure > 60 mmHg), including 361 with a normal BMI (group A), 639 with obesity (Group B), and 137 with morbid obesity (Group C).

One-year mortality rates were 34.1%, in Group A, 22.8% in Group B, and 12.4% in Group C, yielding a lower relative risk (RR) for one-year mortality in groups B (RR 0.616; 95% confidence interval [CI] 0.484-0.530) and C (RR 0.306; 95% CI 0.184-0.508) compared to Group A. One-year readmission rates however did not significantly differ between groups.

"An obesity paradox may also occur in patients with significant pulmonary hypertension," said lead author Dr. Ronald Zolty. "A possible mechanism underlying this phenomenon is increased levels of serum lipoproteins associated with increased body fat, which may play a role in neutralizing circulating toxins and inflammatory proteins."


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Higher BMI associated with lower mortality risk in patients with severe pulmonary hypertension." ScienceDaily. ScienceDaily, 19 May 2014. <www.sciencedaily.com/releases/2014/05/140519184536.htm>.
American Thoracic Society. (2014, May 19). Higher BMI associated with lower mortality risk in patients with severe pulmonary hypertension. ScienceDaily. Retrieved August 19, 2014 from www.sciencedaily.com/releases/2014/05/140519184536.htm
American Thoracic Society. "Higher BMI associated with lower mortality risk in patients with severe pulmonary hypertension." ScienceDaily. www.sciencedaily.com/releases/2014/05/140519184536.htm (accessed August 19, 2014).

Share This




More Health & Medicine News

Tuesday, August 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
American Ebola Patient Apparently Improving, Outbreak Is Not

American Ebola Patient Apparently Improving, Outbreak Is Not

Newsy (Aug. 19, 2014) Nancy Writebol, an American missionary who contracted Ebola, is apparently getting better, according to her husband. The outbreak, however, is not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins