Featured Research

from universities, journals, and other organizations

Nasal bacteria may be predictor of skin infections

Date:
May 21, 2014
Source:
Uniformed Services University of the Health Sciences (USU)
Summary:
Bacteria found in the nose may be a key indicator for future development of skin and soft-tissue infections in remote areas of the body, researchers say. The nose is the primary S. aureus reservoir in humans and nearly 80% of the time, an individual's colonizing strain is the same strain that causes subsequent remote skin infections. Establishing a nose "marker microbiome" associated with development of SSTI infections may pave the way for focused preventive treatments that target the microbiome, rather than S. aureus itself.

Bacteria found in the nose may be a key indicator for future development of skin and soft-tissue infections in remote areas of the body. Scientists have long known that a number of bacteria reside in the nose, and that those who carry the pathogen Staphylococcus aureus in their noses are at a higher risk for developing skin and soft tissue infections (SSTIs). However, until now, no one has been able to determine why some S. aureus carriers develop infections while others do not.

The nose is the primary S. aureus reservoir in humans and nearly 80% of the time, an individual's colonizing strain is the same strain that causes subsequent remote skin infections. Given this association, researchers at the F. Edward Hιbert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Md, postulated that the population of S. aureus in an individual's nose may harbor valuable clues regarding SSTI susceptibility that had not yet been described. This is of particular interest to the military, as it is well known that soldiers in training are at increased risk of developing an SSTI.

In research findings presented this week at the 114th General Meeting of the American Society for Microbiology in Boston, Mass., Ryan Johnson, a graduate student, and his mentor D. Scott Merrell, Ph.D., an Associate Professor in USU's Department of Microbiology and Immunology, in collaboration with USU's Infectious Disease Clinical Research Program, collected nasal samples and cultures from 86 infantry soldiers at Fort Benning, Ga. For those individuals among the 86 who developed SSTIs, the researchers also collected samples and cultures from within the soldiers' skin abscesses.

Using a high-throughput DNA sequencing strategy, the microbial composition of each sample was determined. The biodiversity of the bacterial population in each nose was compared between individuals colonized and/or infected with Methicillin-Resistant S. aureus (MRSA), Methicillin-Sensitive S. aureus (MSSA), and those individuals that were culture-negative for S. aureus. The researchers observed a significantly higher percentage of a type of bacteria known as Proteobacteria in the noses of individuals who did not develop SSTI, suggesting that Proteobacteria may, in fact, be protective against the development of SSTIs. Furthermore, S. aureus carriers had a unique nasal microbiome that differed from non-carriers.

Establishing a nose "marker microbiome" associated with development of SSTI infections may pave the way for focused preventive treatments that target the microbiome, rather than S. aureus itself.

The scientists believe that this study will aid in the design of future prophylactic procedures that can help prevent SSTI, particularly in the setting of military training, and help influence how health care providers think about and treat these complex and diverse infections.


Story Source:

The above story is based on materials provided by Uniformed Services University of the Health Sciences (USU). Note: Materials may be edited for content and length.


Cite This Page:

Uniformed Services University of the Health Sciences (USU). "Nasal bacteria may be predictor of skin infections." ScienceDaily. ScienceDaily, 21 May 2014. <www.sciencedaily.com/releases/2014/05/140521094318.htm>.
Uniformed Services University of the Health Sciences (USU). (2014, May 21). Nasal bacteria may be predictor of skin infections. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2014/05/140521094318.htm
Uniformed Services University of the Health Sciences (USU). "Nasal bacteria may be predictor of skin infections." ScienceDaily. www.sciencedaily.com/releases/2014/05/140521094318.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins