Featured Research

from universities, journals, and other organizations

Disruption of circadian rhythms may contribute to inflammatory disease

Date:
May 21, 2014
Source:
Rush University Medical Center
Summary:
A disruption of circadian rhythms, when combined with a high-fat, high-sugar diet, may contribute to inflammatory bowel disease and other harmful conditions, according to a recent study. "Circadian rhythms, which impose a 24-hour cycle on our bodies, are different from sleep patterns," the first author of the study explained. "Sleep is a consequence of circadian rhythms." While circadian rhythm disruption may be common among some, the research suggests that it may be contributing to a host of diseases.

A disruption of circadian rhythms, when combined with a high-fat, high-sugar diet, may contribute to inflammatory bowel disease and other harmful conditions, according to a recent study conducted by researchers at Rush University Medical Center. The study is online at the peer-reviewed, open-access journal, PLOS ONE.

Related Articles


"Circadian rhythms, which impose a 24-hour cycle on our bodies, are different from sleep patterns," said Robin M. Voigt, PhD, assistant professor at Rush Medical College and first author of the study. "Sleep is a consequence of circadian rhythms," Voigt said.

While circadian rhythm disruption may be common among some, the research suggests that it may be contributing to a host of diseases that may be prevented by regulating things such as sleep/wake patterns and times of eating to help prevent circadian rhythm disruption. Including prebiotics or probiotics in the diet can also help normalize the effects of circadian rhythm disruption on the intestinal microbiota to reduce the presence of inflammation.

"It's something that needs to be addressed -- not something people need to be very concerned about, but aware. If you have some of these other risk factors, like a high-fat, high-sugar diet," or a genetic tendency toward disruption in circadian rhythms, "take precautions, watch your diet, take pre- and probiotics, monitor your health, be vigilant," Voigt said.

The prevailing theory is that of a "second hit hypothesis" whereby individuals with at-risk lifestyle choices or genetic predispositions will only develop disease if a secondary insult is present. "We believe that chronic circadian rhythm disruption promotes/exacerbates inflammatory-mediated diseases, at least in part, due to changes in the intestinal microbiota," she said.

Inflammation is associated with a number of diseases, including cardiovascular disease and cancer, and can cause organ damage and is associated with increased morbidity and mortality.

In the study, male mice had their cycles of exposure to light and dark reversed on a weekly basis (i.e., "shifted"), an experience that is known to disrupt an organism's innate circadian rhythm. Some of the mice ate standard food; others ate a high-fat, high-sugar diet. Researchers found that the microbiota of the mice that had their circadian rhythms disrupted were significantly different from that of the control group -- but only if they had consumed the high-fat, high-sugar diet.

All the mice that ate the high-fat, high-sugar diet displayed changes in the makeup of the microorganisms in their guts, regardless of circadian status. However, mice that ate the high-fat, high-sugar diet, and had circadian-rhythm disruptions, had higher concentrations of bacteria that are known to promote inflammation than any of the other mice in the study. Disrupting the circadian rhythms of the mice fed standard chow did not significantly affect the microbiota in their intestines.

These findings support previous studies that have shown that the negative effects of circadian disruption are subtle enough that "a second environmental insult is often necessary to reveal [their] deleterious effects," the study says.

Many people have their circadian rhythms disrupted on a regular basis -- shift workers like nurses, doctors, firefighters and policemen. "Other people have 'social jet lag,' a lifestyle pattern that leads them to maintain a normal schedule on weekdays, but then stay up late and sleep in on the weekends," Voigt said.

"Looking forward, we would like to functionally evaluate how circadian rhythm disruption may influence diseases including colon cancer, which may in part be the consequence of altered intestinal microbiota," she concluded.


Story Source:

The above story is based on materials provided by Rush University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Robin M. Voigt, Christopher B. Forsyth, Stefan J. Green, Ece Mutlu, Phillip Engen, Martha H. Vitaterna, Fred W. Turek, Ali Keshavarzian. Circadian Disorganization Alters Intestinal Microbiota. PLoS ONE, 2014; 9 (5): e97500 DOI: 10.1371/journal.pone.0097500

Cite This Page:

Rush University Medical Center. "Disruption of circadian rhythms may contribute to inflammatory disease." ScienceDaily. ScienceDaily, 21 May 2014. <www.sciencedaily.com/releases/2014/05/140521175920.htm>.
Rush University Medical Center. (2014, May 21). Disruption of circadian rhythms may contribute to inflammatory disease. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2014/05/140521175920.htm
Rush University Medical Center. "Disruption of circadian rhythms may contribute to inflammatory disease." ScienceDaily. www.sciencedaily.com/releases/2014/05/140521175920.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins