Featured Research

from universities, journals, and other organizations

Genome sequences show how lemurs fight infection

Date:
May 30, 2014
Source:
Duke University
Summary:
Next-generation genome sequencing technology is enabling researchers to catalog 150,000 antibodies found in a single species of lemur that seems uniquely susceptible to cryptosproridium infection. This is a new approach to disease detection and monitoring in a critically endangered species that could aid conservation efforts and surveillance for zoonoses.

Coquerel's sifakas, like this mother-baby pair, are the only lemur species out of 17 at the Duke Lemur Center to fall prey to Cryptosporidium, a waterborne illness that causes weakness and diarrhea. Young sifakas are more likely to get sick, but if researchers can figure out how older animals manage to fight the infection, they might be able to develop vaccines that provide infants the same protection.
Credit: David Haring, Duke Lemur Center

The young lemur named Eugenius started to get sick. Very sick. He was lethargic, losing weight and suffering from diarrhea. Duke Lemur Center veterinarians soon pinpointed the cause of his illness: Eugenius tested positive for Cryptosporidium, a microscopic intestinal parasite known to affect people, pets, livestock and wildlife worldwide.

In humans, thousands of cases of Cryptosporidium are reported in the United States each year, spread primarily through contaminated water.

Since Eugenius was the first animal diagnosed in 1999, the parasite has caused periodic diarrhea outbreaks at the Duke Lemur Center. All of the infected animals are sifakas -- the only lemur species out of 17 at the center known to fall prey to the parasite -- and most of them were under age five when they got sick.

Despite various efforts to stop the infection, such as quarantining infected lemurs and decontaminating their enclosures, more than half of the sifakas living at the center have tested positive for crypto at some point. While most animals recover, the pattern has veterinarians puzzled over why the outbreaks persist.

Now, thanks to advances in next-generation sequencing technology, researchers are getting closer to understanding how these endangered animals fight the infection and detecting the illness early enough to minimize its spread.

In a study published in the May 29, 2014, edition of Molecular Ecology Resources, Duke researchers Peter Larsen, Ryan Campbell and Anne Yoder used high-throughput sequencing on sifaka blood samples to generate sequence data for more than 150,000 different sifaka antibodies -- protective molecules that latch on to bacteria, viruses and other foreign invaders in the body and fight them off before they cause infection.

Traditional sequencing methods can capture only a fraction of the millions of antibodies circulating in the bloodstream at a given time. But faster next-generation sequencing technology lets researchers sequence a much larger portion of the antibody arsenal. The end result is a high-resolution 'snapshot' of antibody diversity that could shed light on how the immune system responds to stress and infection.

The research is part of a growing field called ecoimmunology, which aims to push the study of immunology beyond lab animals like fruit flies and mice and understand how immune systems function in real-world settings outside the lab.

The next step will be to compare blood samples from healthy and sick lemurs, to see if researchers can identify the specific antibodies that play a role in binding to Cryptosporidium and neutralizing the infection -- information that could be key to developing vaccines.

This research will likely lead to new methods of disease detection and treatment for lemurs in captivity, especially infected animals that show no outward signs of being sick. But it also may lead to monitoring the health status of lemurs and other primates living in the wild simply by screening blood samples for antibody patterns indicating exposure to specific parasites.

That's good news for lemurs in their native home of Madagascar, where lemurs live on the brink of extinction, and where human population growth makes contact with people and inter-species exchange of infectious disease increasingly likely.


Story Source:

The above story is based on materials provided by Duke University. Note: Materials may be edited for content and length.


Journal Reference:

  1. P. A. Larsen, C. R. Campbell, A. D. Yoder. Next-generation approaches to advancing eco-immunogenomic research in critically endangered primates. Molecular Ecology Resources, 2014; DOI: 10.1111/1755-0998.12274

Cite This Page:

Duke University. "Genome sequences show how lemurs fight infection." ScienceDaily. ScienceDaily, 30 May 2014. <www.sciencedaily.com/releases/2014/05/140530124418.htm>.
Duke University. (2014, May 30). Genome sequences show how lemurs fight infection. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2014/05/140530124418.htm
Duke University. "Genome sequences show how lemurs fight infection." ScienceDaily. www.sciencedaily.com/releases/2014/05/140530124418.htm (accessed July 24, 2014).

Share This




More Plants & Animals News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Michigan Plant's Goal: Flower and Die

Michigan Plant's Goal: Flower and Die

AP (July 22, 2014) An 80-year-old agave plant, which is blooming for the first and only time at a University of Michigan conservatory, will die when it's done (July 22) Video provided by AP
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins