Featured Research

from universities, journals, and other organizations

Common cholesterol drug greatly alters inflammatory response to common cold

Date:
June 2, 2014
Source:
Federation of American Societies for Experimental Biology
Summary:
Cold season may be just behind us, but a new discovery may shed light on how this common condition triggers asthma attacks. In a new report, researchers show that in individuals with asthma, statins significantly reduce the in vitro inflammatory response of human monocytes to rhinovirus, the cause of the common cold.

Cold season may be just behind us, but a new discovery may shed light on how this common condition triggers asthma attacks. In a new research report published in the June 2014 issue of the Journal of Leukocyte Biology, researchers show that in individuals with asthma, statins significantly reduce the in vitro inflammatory response of human monocytes to rhinovirus (RV), the cause of the common cold. Not only does this discovery suggest that statins could help prevent or reduce the severity of asthma symptoms resulting from colds, but may also open the doors to further research into novel ways of controlling asthma attacks.

Related Articles


"Our findings--that statins reduce rhinovirus-induced CXCL10 secretion from human monocytic cells--suggest that these frequently prescribed drugs may affect asthma exacerbations caused by the common cold in adults," said Lisa E. Wickert, Ph.D., a researcher involved in the work from the Department of Biomolecular Chemistry and Nutritional Sciences at the University of Wisconsin-Madison in Madison, Wisconsin. "We hope that these findings will provide motivation to study how statins not only affect asthma symptoms but more specifically viral-induced asthma exacerbations."

To make their discovery, the researchers isolated human blood monocytes and lung macrophages from patients with allergies and/or asthma and treated the cells with simvastatin, a commonly prescribed statin drug. The cells were then stimulated with three different human RV strains. Researchers compared the inflammatory response of control-treated versus simvastatin-treated cells to RV by measuring CXCL10 secretion, an implicated therapeutic target for virus-induced asthma exacerbations. They found that CXCL10 secretion was lower from simvastatin-treated monocytic cells than in control-treated monocytic cells. In individuals with asthma, statins may modulate the immune response to rhinovirus, which can potentially affect the risk of a viral-induced asthma exacerbation.

"Not only does this report shed light on how colds exacerbate asthma, it also suggests new pathways and existing drugs that might be exploited to limit this, in some cases, severe combination of respiratory events," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, "These findings also highlight an emerging appreciation for the interaction between metabolic pathways and the immune system."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. E. Wickert, M. R. Karta, A. Audhya, J. E. Gern, P. J. Bertics. Simvastatin attenuates rhinovirus-induced interferon and CXCL10 secretion from monocytic cells in vitro. Journal of Leukocyte Biology, 2014; 95 (6): 951 DOI: 10.1189/jlb.0713413

Cite This Page:

Federation of American Societies for Experimental Biology. "Common cholesterol drug greatly alters inflammatory response to common cold." ScienceDaily. ScienceDaily, 2 June 2014. <www.sciencedaily.com/releases/2014/06/140602101706.htm>.
Federation of American Societies for Experimental Biology. (2014, June 2). Common cholesterol drug greatly alters inflammatory response to common cold. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2014/06/140602101706.htm
Federation of American Societies for Experimental Biology. "Common cholesterol drug greatly alters inflammatory response to common cold." ScienceDaily. www.sciencedaily.com/releases/2014/06/140602101706.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins