Featured Research

from universities, journals, and other organizations

Popular artificial sweetener and impact on therapeutic drugs studied

Date:
June 16, 2014
Source:
Taylor & Francis
Summary:
One of the active ingredients in a popular artificial sweetener could have the potential to limit the impact of therapeutic drugs, reduce the number and balance of beneficial bacteria in the gut and alter hormone secretion, according to an article. The article details an experiment involving a popular artificial sweetener, which comprises the high-potency sucralose (1.1%) and the fillers maltodextrin and glucose.

One of the active ingredients in a popular artificial sweetener could have the potential to limit the impact of therapeutic drugs, reduce the number and balance of beneficial bacteria in the gut and alter hormone secretion, according to an article published in Journal of Toxicology and Environmental Health, Part A: Current Issues.

Related Articles


Authored by Susan Schiffman and her colleagues, the article details an experiment involving a popular artificial sweetener, which comprises the high-potency sucralose (1.1%) and the fillers maltodextrin and glucose.

The study involved an experiment using Sprague-Dawley rats that were administered the artificial sweetener over a 12-week period. Following a bacterial analysis of the rats' fecal samples and measurement of fecal pH, the article concluded that artificial sweetener resulted in various adverse effects in the rats, including:

  • Reduction in beneficial fecal microflora
  • Increased fecal pH
  • Enhanced expression levels of P-gp, CYP3A4,and CYP2D1, which are known to limit the bioavailability of orally administered drugs

"At concentrations typically used in foods and drinks, sucralose suppresses beneficial bacteria in the gastrointestinal tract with less effect on pathogenic bacteria," article co-author Susan Schiffman, Ph.D said. "Most consumers are unaware of these effects because no warning label appears on products containing sucralose." Schiffman also said went onto saythat the change in balance of gastrointestinal bacteria has been associated with weight gain and obesity. At elevated levels, sucralose also damages DNA. These biological effects occur at the levels of sucralose currently approved by regulatory agencies for use in the food supply.


Story Source:

The above story is based on materials provided by Taylor & Francis. Note: Materials may be edited for content and length.


Cite This Page:

Taylor & Francis. "Popular artificial sweetener and impact on therapeutic drugs studied." ScienceDaily. ScienceDaily, 16 June 2014. <www.sciencedaily.com/releases/2014/06/140616130720.htm>.
Taylor & Francis. (2014, June 16). Popular artificial sweetener and impact on therapeutic drugs studied. ScienceDaily. Retrieved January 25, 2015 from www.sciencedaily.com/releases/2014/06/140616130720.htm
Taylor & Francis. "Popular artificial sweetener and impact on therapeutic drugs studied." ScienceDaily. www.sciencedaily.com/releases/2014/06/140616130720.htm (accessed January 25, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, January 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins