Featured Research

from universities, journals, and other organizations

Popular artificial sweetener and impact on therapeutic drugs studied

Date:
June 16, 2014
Source:
Taylor & Francis
Summary:
One of the active ingredients in a popular artificial sweetener could have the potential to limit the impact of therapeutic drugs, reduce the number and balance of beneficial bacteria in the gut and alter hormone secretion, according to an article. The article details an experiment involving a popular artificial sweetener, which comprises the high-potency sucralose (1.1%) and the fillers maltodextrin and glucose.

One of the active ingredients in a popular artificial sweetener could have the potential to limit the impact of therapeutic drugs, reduce the number and balance of beneficial bacteria in the gut and alter hormone secretion, according to an article published in Journal of Toxicology and Environmental Health, Part A: Current Issues.

Authored by Susan Schiffman and her colleagues, the article details an experiment involving a popular artificial sweetener, which comprises the high-potency sucralose (1.1%) and the fillers maltodextrin and glucose.

The study involved an experiment using Sprague-Dawley rats that were administered the artificial sweetener over a 12-week period. Following a bacterial analysis of the rats' fecal samples and measurement of fecal pH, the article concluded that artificial sweetener resulted in various adverse effects in the rats, including:

  • Reduction in beneficial fecal microflora
  • Increased fecal pH
  • Enhanced expression levels of P-gp, CYP3A4,and CYP2D1, which are known to limit the bioavailability of orally administered drugs

"At concentrations typically used in foods and drinks, sucralose suppresses beneficial bacteria in the gastrointestinal tract with less effect on pathogenic bacteria," article co-author Susan Schiffman, Ph.D said. "Most consumers are unaware of these effects because no warning label appears on products containing sucralose." Schiffman also said went onto saythat the change in balance of gastrointestinal bacteria has been associated with weight gain and obesity. At elevated levels, sucralose also damages DNA. These biological effects occur at the levels of sucralose currently approved by regulatory agencies for use in the food supply.


Story Source:

The above story is based on materials provided by Taylor & Francis. Note: Materials may be edited for content and length.


Cite This Page:

Taylor & Francis. "Popular artificial sweetener and impact on therapeutic drugs studied." ScienceDaily. ScienceDaily, 16 June 2014. <www.sciencedaily.com/releases/2014/06/140616130720.htm>.
Taylor & Francis. (2014, June 16). Popular artificial sweetener and impact on therapeutic drugs studied. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2014/06/140616130720.htm
Taylor & Francis. "Popular artificial sweetener and impact on therapeutic drugs studied." ScienceDaily. www.sciencedaily.com/releases/2014/06/140616130720.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins