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Microenvironment of hematopoietic stem cells can be a target for myeloproliferative disorders

Date:
June 22, 2014
Source:
Centro Nacional de Investigaciones Cardiovasculares
Summary:
The protective microenvironment of the hematopoietic stem cell niche, which produces cells of the blood and the immune system, also protects against myeloproliferative neoplasia. Protecting this microenvironment, or niche, has thus emerged as a new route for the treatment of these diseases, for which there is currently no fully effective treatment.

This image depicts the authors of the study, including Dr. Mendez and others.
Credit: CNIC

The discovery of a new therapeutic target for certain kinds of myeloproliferative disease is, without doubt, good news. This is precisely the discovery made by the Stem Cell Physiopathology group at the CNIC (the Spanish National Cardiovascular Research Center), led by Dr. Simón Méndez-Ferrer. The team has shown that the microenvironment that controls hematopoietic stem cells can be targeted for the treatment of a set of disorders called myeloproliferative neoplasias, the most prominent of which are chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML), and atypical chronic myelogenous leukemia (CML).

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The findings, published today in Nature, demonstrate that these myeloproliferative neoplasias only appear after damage to the microenvironment that sustains and controls the hematopoietic stem cells -- the cells that produce the cells of the blood and the immune system. Protecting this microenvironment, or niche, has thus emerged as a new route for the treatment of these diseases, for which there is currently no fully effective treatment.

"In normal conditions, the microenvironment is able to control the proliferation, differentiation and migration of the hematopoietic stem cell. A specific genetic mutation in these cells results in inflammatory injury to the microenvironment and this control breaks down. What our work shows is that this damage can be prevented or reversed by treatments that target the niche," explained Dr. Méndez-Ferrer.

Indeed, the same team of researchers has demonstrated the efficacy of a possible new treatment, which has been patented through the CNIC. The treatment involves an innovative use of clinically approved treatments for other diseases, so that, according to the authors, "it shouldn't be associated with adverse side effects." The new treatment route has been tested in animals and has received financial backing for a multicenter phase II clinical trial. "This study has a very strong translational and clinical potential," emphasized study first author Dr. Lorena Arranz, who added that "current treatment for myeloproliferative neoplasias is largely symptomatic and directed at preventing thrombosis and fatal cardiovascular events."

The only real cure available today is a bone marrow transplant, which is not advisable in patients over 50 years old. "This makes it important to identify new therapeutic targets for the development of effective treatments," the investigators conclude.


Story Source:

The above story is based on materials provided by Centro Nacional de Investigaciones Cardiovasculares. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lorena Arranz, Abel Sánchez-Aguilera, Daniel Martín-Pérez, Joan Isern, Xavier Langa, Alexandar Tzankov, Pontus Lundberg, Sandra Muntión, Yi-Shiuan Tzeng, Dar-Ming Lai, Jürg Schwaller, Radek C. Skoda, Simón Méndez-Ferrer. Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms. Nature, 2014; DOI: 10.1038/nature13383

Cite This Page:

Centro Nacional de Investigaciones Cardiovasculares. "Microenvironment of hematopoietic stem cells can be a target for myeloproliferative disorders." ScienceDaily. ScienceDaily, 22 June 2014. <www.sciencedaily.com/releases/2014/06/140622142236.htm>.
Centro Nacional de Investigaciones Cardiovasculares. (2014, June 22). Microenvironment of hematopoietic stem cells can be a target for myeloproliferative disorders. ScienceDaily. Retrieved November 21, 2014 from www.sciencedaily.com/releases/2014/06/140622142236.htm
Centro Nacional de Investigaciones Cardiovasculares. "Microenvironment of hematopoietic stem cells can be a target for myeloproliferative disorders." ScienceDaily. www.sciencedaily.com/releases/2014/06/140622142236.htm (accessed November 21, 2014).

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