Featured Research

from universities, journals, and other organizations

New routine testing for some non-hodgkin lymphomas recommended

Date:
June 26, 2014
Source:
Mayo Clinic
Summary:
Three subgroups of a single type of non-Hodgkin lymphoma that have markedly different survival rates have been discovered by researchers. These subgroups could not be differentiated by routine pathology but only with the aid of novel genetic tests, which the research team recommends giving to all patients with ALK-negative anaplastic large-cell lymphoma (ALCL).

A Mayo Clinic-led group of researchers has discovered three subgroups of a single type of non-Hodgkin lymphoma that have markedly different survival rates. These subgroups could not be differentiated by routine pathology but only with the aid of novel genetic tests, which the research team recommends giving to all patients with ALK-negative anaplastic large-cell lymphoma (ALCL). Findings are published in the journal Blood.

Related Articles


Patients whose lymphomas had TP63 rearrangements had only a 17 percent chance of living five years beyond diagnosis, compared to 90 percent of patients whose tumors had DUSP22 rearrangements. A third group of tumors, those with neither rearrangement, was associated with an intermediate survival rate.

"This is the first study to demonstrate unequivocal genetic and clinical heterogeneity among systemic ALK-negative anaplastic large-cell lymphomas," says Andrew L. Feldman, M.D., a Mayo Clinic pathologist and senior author on the multi-institutional study. "Most strikingly, patients with DUSP22-rearranged ALCL had excellent overall survival rates, while patients with TP63-rearranged ALCL had dismal outcomes and nearly always failed standard therapy." Dr. Feldman also is a Damon Runyon Clinical Investigator.

ALCL is a rare type of non-Hodgkin lymphoma, but one of the more common subtypes of T-cell lymphoma, according to the Lymphoma Research Foundation. ALCL comprises about three percent of all non-Hodgkin lymphoma and 10 to 30 percent of all cases in children. Currently, all ALK-negative anaplastic large-cell lymphomas are treated the same, using chemotherapy and, in some institutions, stem cell transplantation. Results from the study make a clear case for additional testing and possible changes standard of care.

"This is a great example of where individualized medicine can make a difference," says Dr. Feldman. "Patients whose chance of surviving is 1 in 6 are receiving the same therapy as patients whose odds are 9 in 10. Developing tests that identify how tumors are different is a critical step toward being able to tailor therapy to each individual patient."

TP63 and DUSP22 rearrangements are examples of abnormal swapping of DNA that disturbs the way genes are arranged on a tumor cell's chromosomes. These abnormalities cannot be seen in the standard microscopic evaluation that pathologists use to diagnose lymphoma, but can be visualized using a genetic test called fluorescence in situ hybridization (FISH). The authors of the study recommend performing FISH in all patients with ALK-negative anaplastic large-cell lymphoma. Learn more about the new tests:

• 6p25.3 FISH (DUSP22/IRF4): http://www.mayomedicallaboratories.com/test-catalog/Overview/60506

• 3q28 FISH (TP63): http://www.mayomedicallaboratories.com/test-catalog/Overview/70014


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. E. R. Parilla Castellar, E. S. Jaffe, J. W. Said, S. H. Swerdlow, R. P. Ketterling, R. A. Knudson, J. S. Sidhu, E. D. Hsi, S. Karikehalli, L. Jiang, G. Vasmatzis, S. E. Gibson, S. Ondrejka, A. Nicolae, K. L. Grogg, C. Allmer, K. M. Ristow, W. H. Wilson, W. R. Macon, M. E. Law, J. R. Cerhan, T. M. Habermann, S. M. Ansell, A. Dogan, M. J. Maurer, A. L. Feldman. ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. Blood, 2014; DOI: 10.1182/blood-2014-04-571091

Cite This Page:

Mayo Clinic. "New routine testing for some non-hodgkin lymphomas recommended." ScienceDaily. ScienceDaily, 26 June 2014. <www.sciencedaily.com/releases/2014/06/140626132024.htm>.
Mayo Clinic. (2014, June 26). New routine testing for some non-hodgkin lymphomas recommended. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2014/06/140626132024.htm
Mayo Clinic. "New routine testing for some non-hodgkin lymphomas recommended." ScienceDaily. www.sciencedaily.com/releases/2014/06/140626132024.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins