Featured Research

from universities, journals, and other organizations

New routine testing for some non-hodgkin lymphomas recommended

Date:
June 26, 2014
Source:
Mayo Clinic
Summary:
Three subgroups of a single type of non-Hodgkin lymphoma that have markedly different survival rates have been discovered by researchers. These subgroups could not be differentiated by routine pathology but only with the aid of novel genetic tests, which the research team recommends giving to all patients with ALK-negative anaplastic large-cell lymphoma (ALCL).

A Mayo Clinic-led group of researchers has discovered three subgroups of a single type of non-Hodgkin lymphoma that have markedly different survival rates. These subgroups could not be differentiated by routine pathology but only with the aid of novel genetic tests, which the research team recommends giving to all patients with ALK-negative anaplastic large-cell lymphoma (ALCL). Findings are published in the journal Blood.

Patients whose lymphomas had TP63 rearrangements had only a 17 percent chance of living five years beyond diagnosis, compared to 90 percent of patients whose tumors had DUSP22 rearrangements. A third group of tumors, those with neither rearrangement, was associated with an intermediate survival rate.

"This is the first study to demonstrate unequivocal genetic and clinical heterogeneity among systemic ALK-negative anaplastic large-cell lymphomas," says Andrew L. Feldman, M.D., a Mayo Clinic pathologist and senior author on the multi-institutional study. "Most strikingly, patients with DUSP22-rearranged ALCL had excellent overall survival rates, while patients with TP63-rearranged ALCL had dismal outcomes and nearly always failed standard therapy." Dr. Feldman also is a Damon Runyon Clinical Investigator.

ALCL is a rare type of non-Hodgkin lymphoma, but one of the more common subtypes of T-cell lymphoma, according to the Lymphoma Research Foundation. ALCL comprises about three percent of all non-Hodgkin lymphoma and 10 to 30 percent of all cases in children. Currently, all ALK-negative anaplastic large-cell lymphomas are treated the same, using chemotherapy and, in some institutions, stem cell transplantation. Results from the study make a clear case for additional testing and possible changes standard of care.

"This is a great example of where individualized medicine can make a difference," says Dr. Feldman. "Patients whose chance of surviving is 1 in 6 are receiving the same therapy as patients whose odds are 9 in 10. Developing tests that identify how tumors are different is a critical step toward being able to tailor therapy to each individual patient."

TP63 and DUSP22 rearrangements are examples of abnormal swapping of DNA that disturbs the way genes are arranged on a tumor cell's chromosomes. These abnormalities cannot be seen in the standard microscopic evaluation that pathologists use to diagnose lymphoma, but can be visualized using a genetic test called fluorescence in situ hybridization (FISH). The authors of the study recommend performing FISH in all patients with ALK-negative anaplastic large-cell lymphoma. Learn more about the new tests:

• 6p25.3 FISH (DUSP22/IRF4): http://www.mayomedicallaboratories.com/test-catalog/Overview/60506

• 3q28 FISH (TP63): http://www.mayomedicallaboratories.com/test-catalog/Overview/70014


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. E. R. Parilla Castellar, E. S. Jaffe, J. W. Said, S. H. Swerdlow, R. P. Ketterling, R. A. Knudson, J. S. Sidhu, E. D. Hsi, S. Karikehalli, L. Jiang, G. Vasmatzis, S. E. Gibson, S. Ondrejka, A. Nicolae, K. L. Grogg, C. Allmer, K. M. Ristow, W. H. Wilson, W. R. Macon, M. E. Law, J. R. Cerhan, T. M. Habermann, S. M. Ansell, A. Dogan, M. J. Maurer, A. L. Feldman. ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. Blood, 2014; DOI: 10.1182/blood-2014-04-571091

Cite This Page:

Mayo Clinic. "New routine testing for some non-hodgkin lymphomas recommended." ScienceDaily. ScienceDaily, 26 June 2014. <www.sciencedaily.com/releases/2014/06/140626132024.htm>.
Mayo Clinic. (2014, June 26). New routine testing for some non-hodgkin lymphomas recommended. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2014/06/140626132024.htm
Mayo Clinic. "New routine testing for some non-hodgkin lymphomas recommended." ScienceDaily. www.sciencedaily.com/releases/2014/06/140626132024.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
WHO: Ebola Cases to Triple in Weeks Without Drastic Action

WHO: Ebola Cases to Triple in Weeks Without Drastic Action

AFP (Sep. 23, 2014) The number of Ebola infections will triple to 20,000 by November, soaring by thousands every week if efforts to stop the outbreak are not stepped up radically, the WHO warned in a study on Tuesday. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
5 Ways Men Can Prevent Most Heart Attacks

5 Ways Men Can Prevent Most Heart Attacks

Newsy (Sep. 23, 2014) No surprise here: A recent study says men can reduce their risk of heart attack by maintaining a healthy lifestyle, which includes daily exercise. Video provided by Newsy
Powered by NewsLook.com
Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins