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New method to grow zebrafish embryonic stem cells

Date:
June 30, 2014
Source:
Mary Ann Liebert, Inc., Publishers
Summary:
Zebrafish, a model organism that plays an important role in biological research and the discovery and development of new drugs and cell-based therapies, can form embryonic stem cells (ESCs). For the first time, researchers report the ability to maintain zebrafish-derived ESCs for more than two years without the need to grow them on a feeder cell layer.

Zebrafish, a model organism that plays an important role in biological research and the discovery and development of new drugs and cell-based therapies, can form embryonic stem cells (ESCs). For the first time, researchers report the ability to maintain zebrafish-derived ESCs for more than two years without the need to grow them on a feeder cell layer, in a study published in Zebrafish.

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Ho Sing Yee and coauthors from the Malaysian Ministry of Science, Technology and Innovation (Pulau Pinang), Universiti Sains Malaysia (Penang), and National University of Singapore describe the approach they used to be able to maintain zebrafish stem cells in culture and in an undifferentiated state for long periods of time. The ability to establish and grow the zebrafish ESCs without having a feeder layer of cells to support them simplifies their use and could expand their utility. In the article "Derivation and Long-Term Culture of an Embryonic Stem Cell-Like Line from Zebrafish Blastomeres Under Feeder-Free Condition," the authors show that the ESCs retain the morphology, properties, and ability to differentiate into a variety of cell types that is characteristic of ESCs, and were used to generate offspring after transmission through the germline.

"By addressing a major technical bottleneck in the field, this new culture system enables an array of exciting cellular and molecular genetic manipulations for the zebrafish," says Stephen Ekker, PhD, Editor-in-Chief of Zebrafish and Professor of Medicine at Mayo Clinic, Rochester, MN.


Story Source:

The above story is based on materials provided by Mary Ann Liebert, Inc., Publishers. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ho Sing-Yee, Crystal Wei Pin Goh, Gan Jen-Yang, Lee Youn-Sing, Kuen Kuen Millie Lam, Hong Ni, Hong Yunhan, Chan Woon-Khiong, Alexander Chong Shu-Chien. Derivation and Long-Term Culture of an Embryonic Stem Cell-Like Line from Zebrafish Blastomeres Under Feeder-Free Condition. Zebrafish, 2014; 140626074857004 DOI: 10.1089/zeb.2013.0879

Cite This Page:

Mary Ann Liebert, Inc., Publishers. "New method to grow zebrafish embryonic stem cells." ScienceDaily. ScienceDaily, 30 June 2014. <www.sciencedaily.com/releases/2014/06/140630164055.htm>.
Mary Ann Liebert, Inc., Publishers. (2014, June 30). New method to grow zebrafish embryonic stem cells. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2014/06/140630164055.htm
Mary Ann Liebert, Inc., Publishers. "New method to grow zebrafish embryonic stem cells." ScienceDaily. www.sciencedaily.com/releases/2014/06/140630164055.htm (accessed March 2, 2015).

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