Featured Research

from universities, journals, and other organizations

Novel mechanism for invasion of EV71 virus demonstrated

Date:
July 18, 2014
Source:
Springer
Summary:
A novel mechanism for EV71 entry mediated by its receptor SCARB2 has been reported by scientists. These findings make a significant conceptual advance in the understanding of non-enveloped virus entry, to which EV71 belongs. Enterovirus 71 (EV71) is the major causative agent of hand, foot and mouth disease in the Asia-Pacific region. Unlike other enteroviruses, EV71 can cause severe aseptic meningitis, encephalitis, myocarditis and acute flaccid paralysis, thus leading to significant fatality rates.

Enterovirus 71 (EV71) is the major causative agent of hand, foot and mouth disease (HFMD) in the Asia-Pacific region, having caused 8.8 million infections and 3,000 deaths in China in the past five years. Unlike other enteroviruses (e.g. Coxsackievirus), EV71 can cause severe aseptic meningitis, encephalitis, myocarditis and acute flaccid paralysis, thus leading to significant fatality rates.

Unfortunately, the molecular mechanism of EV71 invasion remains poorly understood and there are still no clinically approved therapeutics. Researchers from the Institute of Biophysics, Chinese Academy of Sciences, reported in a study published in Springer's open access journal Protein & Cell a novel mechanism for EV71 entry mediated by its receptor SCARB2. These findings make a significant conceptual advance in the understanding of non-enveloped virus entry, to which EV71 belongs.

In this study, the authors determined the crystal structures of the SCARB2 ectodomain at physiological pH (7.5) and acidic pH (4.8). Comparison of these structures revealed an unexpected pH-dependent conformational change in the EV71 binding sites. At acidic condition, SCARB2 opens up a lipid-transfer tunnel to trigger viral uncoating, releasing the viral genome into the host cell. In addition, the authors demonstrated that the glycosylation of SCARB2 plays a crucial role in attachment and infection of EV71. These results demonstrate how SCARB2 mediates both attachment and uncoating of EV71, and provide valuable information for SCARB2-related drug design against EV71 infection.


Story Source:

The above story is based on materials provided by Springer. Note: Materials may be edited for content and length.


Journal Reference:

  1. Minghao Dang, Xiangxi Wang, Quan Wang, Yaxin Wang, Jianping Lin, Yuna Sun, Xuemei Li, Liguo Zhang, Zhiyong Lou, Junzhi Wang, Zihe Rao. Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71. Protein & Cell, 2014; DOI: 10.1007/s13238-014-0087-3

Cite This Page:

Springer. "Novel mechanism for invasion of EV71 virus demonstrated." ScienceDaily. ScienceDaily, 18 July 2014. <www.sciencedaily.com/releases/2014/07/140718110451.htm>.
Springer. (2014, July 18). Novel mechanism for invasion of EV71 virus demonstrated. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2014/07/140718110451.htm
Springer. "Novel mechanism for invasion of EV71 virus demonstrated." ScienceDaily. www.sciencedaily.com/releases/2014/07/140718110451.htm (accessed October 2, 2014).

Share This



More Plants & Animals News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) — Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com
Cultural Learning In Wild Chimps Observed For The First Time

Cultural Learning In Wild Chimps Observed For The First Time

Newsy (Oct. 1, 2014) — Cultural transmission — the passing of knowledge from one animal to another — has been caught on camera with chimps teaching other chimps. Video provided by Newsy
Powered by NewsLook.com
Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Newsy (Sep. 30, 2014) — A new study published by the World Wide Fund for Nature found that more than half of the world's wildlife population has declined since 1970. Video provided by Newsy
Powered by NewsLook.com
Annual Dog Surfing Competition Draws California Crowds

Annual Dog Surfing Competition Draws California Crowds

AFP (Sep. 30, 2014) — The best canine surfers gathered for Huntington Beach's annual dog surfing competition, "Surf City, Surf Dog." Duration: 01:15 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins