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Novel mechanism for invasion of EV71 virus demonstrated

Date:
July 18, 2014
Source:
Springer
Summary:
A novel mechanism for EV71 entry mediated by its receptor SCARB2 has been reported by scientists. These findings make a significant conceptual advance in the understanding of non-enveloped virus entry, to which EV71 belongs. Enterovirus 71 (EV71) is the major causative agent of hand, foot and mouth disease in the Asia-Pacific region. Unlike other enteroviruses, EV71 can cause severe aseptic meningitis, encephalitis, myocarditis and acute flaccid paralysis, thus leading to significant fatality rates.

Enterovirus 71 (EV71) is the major causative agent of hand, foot and mouth disease (HFMD) in the Asia-Pacific region, having caused 8.8 million infections and 3,000 deaths in China in the past five years. Unlike other enteroviruses (e.g. Coxsackievirus), EV71 can cause severe aseptic meningitis, encephalitis, myocarditis and acute flaccid paralysis, thus leading to significant fatality rates.

Unfortunately, the molecular mechanism of EV71 invasion remains poorly understood and there are still no clinically approved therapeutics. Researchers from the Institute of Biophysics, Chinese Academy of Sciences, reported in a study published in Springer's open access journal Protein & Cell a novel mechanism for EV71 entry mediated by its receptor SCARB2. These findings make a significant conceptual advance in the understanding of non-enveloped virus entry, to which EV71 belongs.

In this study, the authors determined the crystal structures of the SCARB2 ectodomain at physiological pH (7.5) and acidic pH (4.8). Comparison of these structures revealed an unexpected pH-dependent conformational change in the EV71 binding sites. At acidic condition, SCARB2 opens up a lipid-transfer tunnel to trigger viral uncoating, releasing the viral genome into the host cell. In addition, the authors demonstrated that the glycosylation of SCARB2 plays a crucial role in attachment and infection of EV71. These results demonstrate how SCARB2 mediates both attachment and uncoating of EV71, and provide valuable information for SCARB2-related drug design against EV71 infection.


Story Source:

The above story is based on materials provided by Springer. Note: Materials may be edited for content and length.


Journal Reference:

  1. Minghao Dang, Xiangxi Wang, Quan Wang, Yaxin Wang, Jianping Lin, Yuna Sun, Xuemei Li, Liguo Zhang, Zhiyong Lou, Junzhi Wang, Zihe Rao. Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71. Protein & Cell, 2014; DOI: 10.1007/s13238-014-0087-3

Cite This Page:

Springer. "Novel mechanism for invasion of EV71 virus demonstrated." ScienceDaily. ScienceDaily, 18 July 2014. <www.sciencedaily.com/releases/2014/07/140718110451.htm>.
Springer. (2014, July 18). Novel mechanism for invasion of EV71 virus demonstrated. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2014/07/140718110451.htm
Springer. "Novel mechanism for invasion of EV71 virus demonstrated." ScienceDaily. www.sciencedaily.com/releases/2014/07/140718110451.htm (accessed October 23, 2014).

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