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Anti-Wrinkle Compound Causes Pathological Reaction In Skin Cells

Date:
April 11, 2007
Source:
Université Laval
Summary:
Researchers from Université Laval's Faculty of Medicine have discovered that a compound commonly used in many anti-wrinkle products causes a pathological reaction in skin cells. Guillaume Morissette, Lucie Germain, and François Marceau present their conclusions about the mode of action of this substance -- called DMAE -- in the latest edition of the British Journal of Dermatology.
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Compared to normal skin cells (above), cells in a DMAE solution show a dramatic swelling of the vacuoles (center). This swelling increases even more in higher DMAE concentrations (below).
Credit: Université Laval

Researchers from Université Laval's Faculty of Medicine have discovered that a compound commonly used in many antiwrinkle products causes a pathological reaction in skin cells. Guillaume Morissette, Lucie Germain, and François Marceau present their conclusions about the mode of action of this substance--called DMAE--in the latest edition of the British Journal of Dermatology.

DMAE (2-dimethylaminoethanol) is used in many antiwrinkle products dubbed "instant anti-aging face-lifts." This compound, as well as other chemically similar ones, are also found in cosmetics, creams, lipsticks, shampoos, soaps, and baby lotions, although the way they work is not yet understood.

In vitro tests conducted by Dr. Marceau's team revealed that the application of DMAE induces a quick and spectacular swelling of skin cell vacuoles called fibroblasts, which act as reservoirs and interface between the inside and the outside of the cell.

In the hours following the application of DMAE, the researchers observed an important slowing down of cell division--sometimes coming to a complete stop, the inhibition of certain metabolic reactions, and the death of a significant percentage of fibroblasts. The mortality rate of fibroblasts, which varied according to DMAE concentration, was above 25% after 24 hours in the case of a concentration similar to the one resulting from normal use of an antiwrinkle cream. The thickening of the skin induced by the pathological swelling of the fibroblasts would explain the antiwrinkle effect of DMAE, according to the researchers.

"Even though DMAE is similar to medication, there is very little scientific documentation about its pharmacological and toxicological effects," explains Dr. Marceau, who stresses his goal is not to condemn the use of this compound. "We're not saying DMAE is dangerous to people exposed to it, but our results indicate it's time to begin serious research to determine whether or not it poses a health risk."

DMAE is not a unique case in the world of beauty products, continues the researcher. "Several compounds found in cosmetics are just as complex as medication--they are absorbed through the skin, flow through the bloodstream, are expelled by the kidneys, or stocked in cells or even in the liver. Yet, the laws regulating their use are far less restrictive than those regulating drugs," concludes Dr. Marceau.


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Materials provided by Université Laval. Note: Content may be edited for style and length.


Cite This Page:

Université Laval. "Anti-Wrinkle Compound Causes Pathological Reaction In Skin Cells." ScienceDaily. ScienceDaily, 11 April 2007. <www.sciencedaily.com/releases/2007/04/070411105944.htm>.
Université Laval. (2007, April 11). Anti-Wrinkle Compound Causes Pathological Reaction In Skin Cells. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2007/04/070411105944.htm
Université Laval. "Anti-Wrinkle Compound Causes Pathological Reaction In Skin Cells." ScienceDaily. www.sciencedaily.com/releases/2007/04/070411105944.htm (accessed May 23, 2017).

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