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Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia

Date:
September 8, 2014
Source:
The Lancet
Summary:
Chronic obstructive pulmonary disease is associated with eosinophilic airway inflammation in 10–20 percent of patients. Benralizumab, a monoclonal antibody, has been shown to decrease the number of blood and sputum eosinophils.
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Chronic obstructive pulmonary disease (COPD) is associated with eosinophilic airway inflammation in 10-20% of patients.

Benralizumab, a monoclonal antibody, has been shown to decrease the number of blood and sputum eosinophils.

In this trial of 101 patients with COPD whether benralizumab reduces the number of acute exacerbations was investigated. Benralizumab was found to be no more effective at preventing acute COPD exacerbations than placebo overall. However, the authors conclude that subgroup analyses suggest more research into the use of benralizumab in patients with COPD and eosinophilia is required.


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Materials provided by The Lancet. Note: Content may be edited for style and length.


Journal Reference:

  1. Christopher E Brightling, Eugene R Bleecker, Reynold A Panettieri, Mona Bafadhel, Dewei She, Christine K Ward, Xiao Xu, Claire Birrell, René van der Merwe. Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study. The Lancet Respiratory Medicine, 2014; DOI: 10.1016/S2213-2600(14)70187-0

Cite This Page:

The Lancet. "Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia." ScienceDaily. ScienceDaily, 8 September 2014. <www.sciencedaily.com/releases/2014/09/140908083752.htm>.
The Lancet. (2014, September 8). Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia. ScienceDaily. Retrieved July 14, 2024 from www.sciencedaily.com/releases/2014/09/140908083752.htm
The Lancet. "Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia." ScienceDaily. www.sciencedaily.com/releases/2014/09/140908083752.htm (accessed July 14, 2024).

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