Pharmaceuticals News
March 30, 2017

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updated 8:50pm EDT

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March 30, 2017

Alcohol Use in Veterans With Schizophrenia Less Common Than Thought; No Level Safe

Mar. 28, 2017 — US veterans who are being treated for schizophrenia are much less likely to drink any alcohol than the general population. But when they do misuse alcohol, it leads to worsening of their ... read more

Potential Drugs and Targets for Brain Repair

Mar. 28, 2017 — Researchers have discovered drugs that activate signaling pathways leading to specific adult brain cell types from stem cells in the mouse brain, according to a new study. The results may open new ... read more

Mar. 24, 2017 — The U.S. Food and Drug Administration has granted accelerated approval to the checkpoint inhibitor Bavencio (avelumab) for the treatment of patients with metastatic Merkel cell ... read more

Nanoparticle Paves the Way for New Triple Negative Breast Cancer Drug

Mar. 24, 2017 — A potential new drug to tackle the highly aggressive ‘triple negative’ breast cancer – and a nanoparticle to deliver it directly into the cancer cells – has been developed by ... read more

'First in Human' Trial Defines Safe Dosage for Small Molecule Drug ONC201 for Solid Cancer Tumors

Mar. 22, 2017 — A ‘first in human’ clinical trial examining the small molecule drug ONC201 in cancer patients with advanced solid tumors shows that this investigational drug is well tolerated at the recommended ... read more

Mar. 22, 2017 — Since a couple of decades, metal-containing drugs have been successfully used to fight against certain types of cancer. The lack of knowledge about the underlying molecular mechanisms slows down the ... read more

Shortage of Drug to Treat Low Blood Pressure from Septic Shock Associated With Increased Deaths

Mar. 21, 2017 — Patients with septic shock admitted to hospitals affected by the 2011 shortage of the drug norepinephrine had a higher risk of in-hospital death, according to a ... read more

Mar. 20, 2017 — Genetic mutations that cause cancer also weaken cancer cells, allowing researchers to develop drugs that will selectively kill them. This is called "synthetic lethality" because the drug is ... read more

Researchers Discover Key to Drug Resistance in Common Breast Cancer Treatment

Mar. 20, 2017 — Three-quarters of all breast cancer tumors are driven by the hormone estrogen. These tumors are frequently treated with drugs to suppress estrogen receptor activity, but unfortunately, at least half ... read more

Pembrolizumab Shows Promise in Treatment of Mesothelioma

Mar. 20, 2017 — Pembrolizumab, an antibody drug already used to treat other forms of cancer, can be effective in the treatment of the most common form of mesothelioma, according to a new study. The work is the first ... read more

Tethered Nanoparticles Make Tumor Cells More Vulnerable

Mar. 20, 2017 — Researchers have devised a way to make cancer cells more susceptible to certain types of cancer treatment, by coating the cells with nanoparticles before delivering drugs. By tethering hundreds of ... read more

Concerns About Heightened Risk of Death for AFib Patients Taking Digoxin

Mar. 20, 2017 — Patients with atrial fibrillation (AFib) who are given digoxin to control their symptoms have an increased risk of death, whether or not they have a diagnosis of heart failure, compared with patients ... read more

Researchers Review Progress of Treating Glutamate Signalling in Depression

Mar. 17, 2017 — Major depressive disorder (MDD) impacts 15 million Americans and is the leading cause of disability, yet current treatments possess limited efficacy. Ketamine, which has been repurposed as a rapidly ... read more

PCSK9 Inhibitior Bococizumab Produces Varying Results

Mar. 17, 2017 — Researchers report that bococizumab had short-term benefits on lowering cholesterol levels and significantly reduced the risk of cardiovascular events by 21 percent compared to placebo among those ... read more

Reduced Dose of Warfarin Alternative May Help Prevent Strokes in Dialysis Patients

Mar. 16, 2017 — In dialysis patients who took 2.5 mg of apixaban twice daily, blood concentrations of the drug were maintained at therapeutic ... read more

New Drug Delivery Method for Cancer Therapy Developed

Mar. 16, 2017 — Scientists have developed a new drug delivery method that produces strong results in treating cancers in animal models, including some hard-to-treat solid and liquid ... read more

Old Target, New Mechanism for Overcoming Tuberculosis Resistance

Mar. 16, 2017 — In strains of tuberculosis that have developed drug resistance mutations, researchers have identified a secondary pathway that can be activated to reinstate drug ... read more

Glioblastoma Clinical Trial Shows Combined Therapy Extends Life for Patients 65 and Older

Mar. 15, 2017 — Treating older patients who have malignant brain cancer with the chemotherapy drug temozolomide plus a short course of radiation therapy extends survival by two months compared to treating with ... read more

New Method for Producing Leading Anti-Malarial Drug

Mar. 15, 2017 — Researchers have devised a new way of creating a drug commonly used as the first line of defense against malaria around the ... read more

Study Finds No Benefit, but Possible Harm, from Drug Used to Prevent Preterm Births

Mar. 14, 2017 — A drug commonly prescribed to pregnant women with a history of delivering babies early provides no benefit. In fact, this drug may even increase the risk of developing gestational ... read more

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