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Treatment against seasonal hay fever should be initiated prior to season, study shows

Date:
May 4, 2015
Source:
University of Oslo, Faculty of Medicine
Summary:
Allergen-specific T cells are resident in the mucosa outside the pollen season and react strongly to pollen extract, suggesting that these T cells are long-lived resident memory cells, researchers say. As a result, they suggest that treatment for hay fever be initiated prior to the traditional hay fever season.
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Antigen-presenting cells (red) activating T-cells (green) in biopsies from the nasal mucosa.
Credit: Image courtesy of University of Oslo, Faculty of Medicine

Recently published findings from the University of Oslo show that allergen-specific T cells are resident in the mucosa outside the pollen season and react strongly to pollen extract, suggesting that these T cells are long-lived resident memory cells.

Researchers at the Centre for Immune Regulation, University of Oslo, have recently published findings showing that seasonal hay fever can be induced outside of the pollen season. This may have an important impact on our approach to the treatment of seasonal hay fever.

The results indicate that anti-inflammatory therapy in seasonal hay fever targeted at allergen-specific T cells should be initiated prior to season.

By challenging nasal biopsies ex vivo during the winter time, the team show that allergen-specific T cells are resident in the mucosa outside the pollen season and react strongly to pollen extract. This suggests that these T cells are long-lived resident memory cells.

Local T cells orchestrate the inflammatory reaction in seasonal hay fever by producing cytokines that activate immune cells and stromal cells. However, it has long been unknown whether allergen-specific T cells reside in the mucosa outside the season or whether they are recruited from the circulation when the nasal mucosa is exposed to allergen (e.g. pollen). The results from this study provide evidence to the former, thus deepening our understanding of the mechanisms behind hay fever and how to approach it therapeutically.


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Materials provided by University of Oslo, Faculty of Medicine. Note: Content may be edited for style and length.


Journal Reference:

  1. Ingebjørg Skrindo, Christina Hoffmann, Einar Gran, Finn-Eirik Johansen, Espen S Baekkevold, Frode L Jahnsen. IL-5 production by resident mucosal allergen-specific T cells in an explant model of allergic rhinitis. Clinical & Experimental Allergy, 2015; DOI: 10.1111/cea.12543

Cite This Page:

University of Oslo, Faculty of Medicine. "Treatment against seasonal hay fever should be initiated prior to season, study shows." ScienceDaily. ScienceDaily, 4 May 2015. <www.sciencedaily.com/releases/2015/05/150504103421.htm>.
University of Oslo, Faculty of Medicine. (2015, May 4). Treatment against seasonal hay fever should be initiated prior to season, study shows. ScienceDaily. Retrieved May 22, 2017 from www.sciencedaily.com/releases/2015/05/150504103421.htm
University of Oslo, Faculty of Medicine. "Treatment against seasonal hay fever should be initiated prior to season, study shows." ScienceDaily. www.sciencedaily.com/releases/2015/05/150504103421.htm (accessed May 22, 2017).

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