Science News
from research organizations

Why the bloating during menopause? Blame the hormones or the lack of them

Date:
June 22, 2015
Source:
American Physiological Society (APS)
Summary:
Many women experience water retention and bloating when their hormone levels change, but how sex hormones affect water balance is not understood. A new study offers an explanation, finding that sex hormones can directly control how the body reabsorbs water.
Share:
FULL STORY

Water retention -- a cause of bloating -- is associated with changes in sex hormone levels. Many women experience water retention during menopause, but how sex hormones affect water balance is not understood. A new study in in the American Journal of Physiology -- Renal Physiology sheds light on the connection, finding that sex hormones can directly control how the body reabsorbs water.

Water level in the body is maintained by the kidneys, which controls the amount of water reabsorbed from the blood they filter. Water is reabsorbed through channels called aquaporin 2 (AQP2) that are found along the kidneys' ducts. How much is reabsorbed is affected by the amount of AQP2.

Female rats with their ovaries removed produced less urine and had more AQP2 channels in their kidneys compared with female rats with ovaries. Treating the rats with the female sex hormone estradiol increased urine output and decreased the amount of AQP2. According to the researchers, the data supported that estradiol had an inhibitory effect on AQP2, meaning the lower the estradiol level, the greater the water retention. Changes in sex hormone levels over the menstrual cycle may affect the kidneys' water handling, and the reduced level of hormones during menopause may explain the greater water retention, the researchers wrote.


Story Source:

Materials provided by American Physiological Society (APS). Note: Content may be edited for style and length.


Journal Reference:

  1. Muhammad Umar Cheema, Debra L Irsik, Yan Wang, William Miller-Little, Kelly A Hyndman, Eileen S Marks, Jørgen Frøkiær, Erika I. Boesen, Rikke Norregaard. Estradiol regulates AQP2 expression in the collecting duct - a novel inhibitory role for estrogen receptor alpha. American Journal of Physiology - Renal Physiology, 2015; ajprenal.00685.2014 DOI: 10.1152/ajprenal.00685.2014

Cite This Page:

American Physiological Society (APS). "Why the bloating during menopause? Blame the hormones or the lack of them." ScienceDaily. ScienceDaily, 22 June 2015. <www.sciencedaily.com/releases/2015/06/150622071855.htm>.
American Physiological Society (APS). (2015, June 22). Why the bloating during menopause? Blame the hormones or the lack of them. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2015/06/150622071855.htm
American Physiological Society (APS). "Why the bloating during menopause? Blame the hormones or the lack of them." ScienceDaily. www.sciencedaily.com/releases/2015/06/150622071855.htm (accessed May 26, 2017).

RELATED STORIES