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How to use the good to combat the bad in cardiovascular disease

Date:
July 1, 2015
Source:
American Physiological Society (APS)
Summary:
New research shows that cardiovascular disease conditions trigger pathways that protect the blood vessels. The response may be a new therapeutic strategy for cardiovascular disease.
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Changes in blood flow pattern, such as from plaque build-up in the arteries, initiate a cascade of conflicting signals. Some responses damage the blood vessel, while others heal it.

A new study in American Journal of Physiology -- Heart and Circulatory Physiology identifies the involvement of a protective response pathway, the heme oxygenase system, that has potential as a new therapeutic strategy for cardiovascular diseases.

In the study, researchers from Mayo Clinic in Rochester, Minn., demonstrated that reducing blood flow activated the heme oxygenase genes. Activation of the genes enlarged the artery to restore blood flow and mitigated the blood vessel injury that follows blood flow pattern changes.

This study is the first to demonstrate the importance of the heme oxygenase system in responding to changes in blood flow pattern and the possibility of using it to treat cardiovascular diseases, the researchers wrote.


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Materials provided by American Physiological Society (APS). Note: Content may be edited for style and length.


Journal Reference:

  1. Lu Kang, Matthew L. Hillestad, Joseph P. Grande, Anthony J. Croatt, Michael A. Barry, Gianrico Farrugia, Zvonimir S. Katusic, Karl A. Nath. Induction and functional significance of the heme oxygenase system in pathological shear stress in vivo. American Journal of Physiology - Heart and Circulatory Physiology, 2015; 308 (11): H1402 DOI: 10.1152/ajpheart.00882.2014

Cite This Page:

American Physiological Society (APS). "How to use the good to combat the bad in cardiovascular disease." ScienceDaily. ScienceDaily, 1 July 2015. <www.sciencedaily.com/releases/2015/07/150701152636.htm>.
American Physiological Society (APS). (2015, July 1). How to use the good to combat the bad in cardiovascular disease. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/07/150701152636.htm
American Physiological Society (APS). "How to use the good to combat the bad in cardiovascular disease." ScienceDaily. www.sciencedaily.com/releases/2015/07/150701152636.htm (accessed May 23, 2017).

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