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Gold-diamond nanodevice for hyperlocalized cancer therapy

Gold nanorods can be used as remote controlled nanoheaters delivering the right amount of thermal treatment to cancer cells, thanks to diamond nanocrystals used as temperature sensors

Date:
July 31, 2015
Source:
Springer
Summary:
Precise targeting biological molecules, such as cancer cells, for treatment is a challenge, due to their sheer size. Now, scientists have proposed an advanced solution that can potentially be applied to thermal cancer therapy. An improved sensing technique for nanometer-scale heating and temperature sensing uses a chemical method to attach gold nanorods to the surface of a diamond nanocrystal, the authors have invented a new biocompatible nanodevice.
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Precise targeting biological molecules, such as cancer cells, for treatment is a challenge, due to their sheer size. Now ,Taiwanese scientists have proposed an advanced solution, based on a novel combination of previously used techniques, which can potentially be applied to thermal cancer therapy. Pei-Chang Tsai from the Institute of Atomic and Molecular Sciences, at the Academia Sinica, Taipei, and colleagues just published in EPJ QT an improved sensing technique for nanometre-scale heating and temperature sensing. Using a chemical method to attach gold nanorods to the surface of a diamond nanocrystal, the authors have invented a new biocompatible nanodevice. It is capable of delivering extremely localized heating from a near-infrared laser aimed at the gold nanorods, while accurately sensing temperature with the nanocrystals.

The authors' lab specializes in fabricating bright fluorescent diamond nanocrystals. The paticularity of these nanocrystals is that they contain a high concentration of punctual colour centre defects. When exposed to green light, these centres emit a red fluorescent light, useful for sub-cellular imaging applications. Unlike ordinary fluorescent material, these centres can also be turned into hypersensitive nanoprobes to detect temperature and magnetic field, via optical manipulation and detection.

By introducing gold nanoparticles to the nanocrystal, the authors make it possible to convert the incoming laser light into extremely localized heat. These gold nanoparticles can therefore act as switchable nanoheaters for therapies based on delivering intense and precise heat to cancerous cells, using a laser as the energy source. The novelty of this study is that it shows that it is possible to use diamond nanocrystals as hypersensitive temperature sensors with a high spatial resolution -- ranging from 10 to 100 nanometers -- to monitor the amount of heat delivered to cancer cells.


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Journal Reference:

  1. Pei-Chang Tsai, Oliver Y Chen, Yan-Kai Tzeng, Yuen Yung Hui, Jiun You Guo, Chih-Che Wu, Ming-Shien Chang, Huan-Cheng Chang. Gold/diamond nanohybrids for quantum sensing applications. EPJ Quantum Technology, 2015; 2 (1) DOI: 10.1140/epjqt/s40507-015-0031-3

Cite This Page:

Springer. "Gold-diamond nanodevice for hyperlocalized cancer therapy: Gold nanorods can be used as remote controlled nanoheaters delivering the right amount of thermal treatment to cancer cells, thanks to diamond nanocrystals used as temperature sensors." ScienceDaily. ScienceDaily, 31 July 2015. <www.sciencedaily.com/releases/2015/07/150731103651.htm>.
Springer. (2015, July 31). Gold-diamond nanodevice for hyperlocalized cancer therapy: Gold nanorods can be used as remote controlled nanoheaters delivering the right amount of thermal treatment to cancer cells, thanks to diamond nanocrystals used as temperature sensors. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/07/150731103651.htm
Springer. "Gold-diamond nanodevice for hyperlocalized cancer therapy: Gold nanorods can be used as remote controlled nanoheaters delivering the right amount of thermal treatment to cancer cells, thanks to diamond nanocrystals used as temperature sensors." ScienceDaily. www.sciencedaily.com/releases/2015/07/150731103651.htm (accessed May 23, 2017).

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