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Knee-deep in spider leg evolution

Date:
October 6, 2015
Source:
Molecular Biology and Evolution (Oxford University Press)
Summary:
Biologists have identified the driving force behind the evolution of a leg novelty first found in spiders: knees.
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On the left is a spider embryo expressing the "old" dac gene (dac1) and, on the right, another spider embryo expressing the "new" dac gene (dac2).
Credit: Courtesy of: Nikola-Michael Prpic Göttinger Zentrum für Molekulare Biowissenschaften, Universität Göttingen, Germany

Authors Nikola-Michael Prpic et al., in a new study appearing in the advanced online edition of Molecular Biology and Evolution, have identified the driving force behind the evolution of a leg novelty first found in spiders: knees.

With eight hairy legs and seven joints on each -- that's a lot for a spider to coordinate just to take a single step. Prpic's research team honed in on a gene called dachshund (dac). The gene was first discovered in fruit flies, and humorously named for the missing leg segments and shortened legs that result from dac mutant flies.

But arachnids are different than flies and other arthropods, possessing a second dac gene. And the dac2 gene is made only in the kneecap, or patella, during spider development.

When the research group used RNA interference experiments to specifically deactivate dac2, the kneecap fuses to the tibia into a single leg segment. The force behind knees first appearing on the spider evolutionary scene was a result of ancient gene duplication in the original dac that, over time, evolved into an entirely new function and way of unique way of walking about for spiders.

"Species constantly adapt and evolve by inventing new body features," said Prpic. "Our work shows how a gene can be duplicated and then used during evolution to invent a new morphological feature."


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Materials provided by Molecular Biology and Evolution (Oxford University Press). Note: Content may be edited for style and length.


Journal Reference:

  1. Natascha Turetzek, Matthias Pechmann, Christoph Schomburg, Julia Schneider, Nikola-Michael Prpic. Neofunctionalisation of a duplicatedachshundgene underlies the evolution of a novel leg segment in arachnids. Molecular Biology and Evolution, 2015; msv200 DOI: 10.1093/molbev/msv200

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Molecular Biology and Evolution (Oxford University Press). "Knee-deep in spider leg evolution." ScienceDaily. ScienceDaily, 6 October 2015. <www.sciencedaily.com/releases/2015/10/151006192026.htm>.
Molecular Biology and Evolution (Oxford University Press). (2015, October 6). Knee-deep in spider leg evolution. ScienceDaily. Retrieved May 27, 2017 from www.sciencedaily.com/releases/2015/10/151006192026.htm
Molecular Biology and Evolution (Oxford University Press). "Knee-deep in spider leg evolution." ScienceDaily. www.sciencedaily.com/releases/2015/10/151006192026.htm (accessed May 27, 2017).

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