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Brain connectivity changes with working memory after TBI

Novel TBI study shows causal relationship between CapMan tasks of working memory and fronto-parietal regions

Date:
October 20, 2015
Source:
Kessler Foundation
Summary:
Scientists compared information flow in the brain in traumatic brain injury and controls using neuroimaging and a novel working memory task, CapMan, which measures capacity and mental manipulation. This is the first study to show causal relationship between these tasks of working memory and fronto-parietal regions.
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Scientists at Kessler Foundation apply the latest in neuroimaging techniques to cognitive rehabilitation research in multiple sclerosis, brain injury and stroke. Neuroimaging is conducted at the state-of-the-art Rocco Ortenzio Neuroimaging Center at Kessler Foundation.
Credit: Kessler Foundation

Scientists from Kessler Foundation and Rutgers University compared information flow in the brain in individuals with traumatic brain injury and healthy controls, using neuroimaging and a novel working memory task, CapMan, which measures both working memory capacity and the mental manipulation of information in working memory. This is the first such comparative study to show a causal relationship between these tasks of working memory and the fronto-parietal regions. "Investigation of Information Flow During a Novel Working Memory Task in Individuals with Traumatic Brain Injury," (doi:10.1089/brain.2014.0283) was published in Brain Connectivity; authors are Ekaterina Dobryakova, PhD, and Glenn Wylie, DPhil, of Kessler Foundation and Olga Boukrina, PhD, of Rutgers University.

Working memory, which involves a network of fronto-parietal regions, is often impaired by the axonal shearing that characterizes TBI. Few studies have looked at the flow of information in working memory after TBI. In this study, researchers compared 11 people with chronic moderate to severe TBI with 15 healthy controls; all performed CapMan tasks during functional magnetic resonance imaging. On fMRI, the TBI group showed hyperconnectivity between the fronto-parietal regions and less organized flow of information related to working memory.

"The effective connectivity analysis used in this study revealed how the neural mechanisms of working memory differ after brain injury," said Dr. Wylie, associate director of the Rocco Ortenzio Neuroimaging Center at Kessler Foundation. "Knowing the pattern of working memory deficits will help us develop effective interventions for improving rehabilitation for individuals with TBI."


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Materials provided by Kessler Foundation. Note: Content may be edited for style and length.


Journal Reference:

  1. Ekaterina Dobryakova, Olga Boukrina, Glenn R. Wylie. Investigation of Information Flow During a Novel Working Memory Task in Individuals with Traumatic Brain Injury. Brain Connectivity, 2015; 5 (7): 433 DOI: 10.1089/brain.2014.0283

Cite This Page:

Kessler Foundation. "Brain connectivity changes with working memory after TBI: Novel TBI study shows causal relationship between CapMan tasks of working memory and fronto-parietal regions." ScienceDaily. ScienceDaily, 20 October 2015. <www.sciencedaily.com/releases/2015/10/151020145231.htm>.
Kessler Foundation. (2015, October 20). Brain connectivity changes with working memory after TBI: Novel TBI study shows causal relationship between CapMan tasks of working memory and fronto-parietal regions. ScienceDaily. Retrieved May 28, 2017 from www.sciencedaily.com/releases/2015/10/151020145231.htm
Kessler Foundation. "Brain connectivity changes with working memory after TBI: Novel TBI study shows causal relationship between CapMan tasks of working memory and fronto-parietal regions." ScienceDaily. www.sciencedaily.com/releases/2015/10/151020145231.htm (accessed May 28, 2017).