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Using glucose monitors to detect other diseases

Date:
March 30, 2016
Source:
American Chemical Society
Summary:
Diagnosing disease can be highly technical, costly and time-consuming, which are all challenges that become particularly problematic in low-income and remote locations. Now scientists are reporting a new way to repurpose portable glucose monitors to harness these simple devices' practicality and low cost for the detection of other diseases.
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Diagnosing disease can be highly technical, costly and time-consuming, which are all challenges that become particularly problematic in low-income and remote locations. Now scientists are reporting in the journal ACS Applied Materials & Interfaces a new way to repurpose portable glucose monitors to harness these simple devices' practicality and low cost for the detection of other diseases.

There are many benefits to diagnosing disease quickly. Treatment can start earlier, which can lead to better outcomes. It saves time and money. It can also minimize patients' anxiety as they wait for results. But rapid diagnoses aren't always possible using current technology. The personal glucose monitor, however, is one medical testing device that can deliver results rapidly. Building on its success, scientists have started repurposing it to test for other substances, such as cocaine or Salmonella bacteria in milk. But the methods they used so far required complicated and time-consuming steps. Chaoyong James Yang and colleagues wanted to take a simpler approach and apply it to biological disease markers.

The researchers started with tiny spherical pouches called liposomes and filled them with enzymes that produce glucose. In the presence of a target molecule, the liposomes were designed to burst open and cause an increase of glucose in the test solution. The researchers tried it with thrombin, a protein that can indicate restricted blood flow or heart disease. A commercial glucose monitor accurately detected the levels of glucose, which corresponded to the amount of thrombin in samples. In addition, the researchers say their method could be used to detect other disease-associated proteins.


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Materials provided by American Chemical Society. Note: Content may be edited for style and length.


Journal Reference:

  1. Bingqian Lin, Dan Liu, Jinmao Yan, Zhi Qiao, Yunxin Zhong, Jiawei Yan, Zhi Zhu, Tianhai Ji, Chaoyong James Yang. Enzyme-Encapsulated Liposome-Linked Immunosorbent Assay Enabling Sensitive Personal Glucose Meter Readout for Portable Detection of Disease Biomarkers. ACS Applied Materials & Interfaces, 2016; 8 (11): 6890 DOI: 10.1021/acsami.6b00777

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American Chemical Society. "Using glucose monitors to detect other diseases." ScienceDaily. ScienceDaily, 30 March 2016. <www.sciencedaily.com/releases/2016/03/160330122644.htm>.
American Chemical Society. (2016, March 30). Using glucose monitors to detect other diseases. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2016/03/160330122644.htm
American Chemical Society. "Using glucose monitors to detect other diseases." ScienceDaily. www.sciencedaily.com/releases/2016/03/160330122644.htm (accessed May 24, 2017).

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