Science News
from research organizations

New method to reduce accumulation of damaging Huntington's disease protein

Date:
April 15, 2016
Source:
University of California - Irvine
Summary:
There may be a new way to change the damaging course of Huntington disease, researchers report. They have shown that reducing the aberrant accumulation of a particular form of the mutant Huntingtin protein corresponds to improvement in symptoms and neuroinflammation in HD mice.
Share:
FULL STORY

A study appearing April 14 in the journal Neuron suggests there may be a new way to change the damaging course of Huntington disease.

University of California, Irvine neurobiologists Leslie Thompson and Joseph Ochaba with the Departments of Neurobiology & Behavior and Psychiatry & Human Behavior and their colleagues from UCI and from Children's Hospital of Philadelphia have shown that reducing the aberrant accumulation of a particular form of the mutant Huntingtin protein corresponds to improvement in symptoms and neuroinflammation in HD mice.

They showed this by targeting and modulating levels of PIAS1 -- a protein implicated in cancer and other diseases -- which they found led to the reduction of the mutant Huntington protein. The work suggests that changing levels of the PIAS1 protein and targeting this pathway could have a benefit to disease.

There are no current treatments for HD, although Thompson's ongoing work with stem cell-based therapies are showing promise.


Story Source:

Materials provided by University of California - Irvine. Note: Content may be edited for style and length.


Journal Reference:

  1. Joseph Ochaba, Alex Mas Monteys, Jacqueline G. O’Rourke, Jack C. Reidling, Joan S. Steffan, Beverly L. Davidson, Leslie M. Thompson. PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo. Neuron, 2016; DOI: 10.1016/j.neuron.2016.03.016

Cite This Page:

University of California - Irvine. "New method to reduce accumulation of damaging Huntington's disease protein." ScienceDaily. ScienceDaily, 15 April 2016. <www.sciencedaily.com/releases/2016/04/160415143617.htm>.
University of California - Irvine. (2016, April 15). New method to reduce accumulation of damaging Huntington's disease protein. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/04/160415143617.htm
University of California - Irvine. "New method to reduce accumulation of damaging Huntington's disease protein." ScienceDaily. www.sciencedaily.com/releases/2016/04/160415143617.htm (accessed May 23, 2017).

RELATED STORIES