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Children with and without multiple sclerosis have differences in gut bacteria

Date:
May 17, 2016
Source:
Wiley
Summary:
In a recent study, children with multiple sclerosis had differences in the abundance of specific gut bacteria than children without the disease. Certain types of bacteria were either more or less abundant in children with multiple sclerosis. In particular, there was an association between multiple sclerosis and an increase in gut bacteria that have been linked to inflammation and a decrease in gut bacteria that are considered anti-inflammatory.
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In a recent study, children with multiple sclerosis had differences in the abundance of specific gut bacteria than children without the disease. Certain types of bacteria were either more or less abundant in children with multiple sclerosis. In particular, there was an association between multiple sclerosis and an increase in gut bacteria that have been linked to inflammation and a decrease in gut bacteria that are considered anti-inflammatory.

A better understanding of gut bacteria's role in multiple sclerosis may identify novel drug targets and pathways to improved health.

"While these findings are preliminary, they are intriguing. We also observed some similarities between our findings and other emerging gut microbiota studies in multiple sclerosis; whether these indicate a 'gut signature' of multiple sclerosis or of broader autoimmune disease remains to be determined," said Professor Helen Tremlett, lead author of the European Journal of Neurology study. "We also found differences in the gut microbiota composition between those children taking a disease-modifying drug for their disease compared with those who were not. This finding warrants further study."


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Journal Reference:

  1. H. Tremlett, D. W. Fadrosh, A. A. Faruqi, F. Zhu, J. Hart, S. Roalstad, J. Graves, S. Lynch, E. Waubant. Gut microbiota in early pediatric multiple sclerosis: a case−control study. European Journal of Neurology, 2016; DOI: 10.1111/ene.13026

Cite This Page:

Wiley. "Children with and without multiple sclerosis have differences in gut bacteria." ScienceDaily. ScienceDaily, 17 May 2016. <www.sciencedaily.com/releases/2016/05/160517083454.htm>.
Wiley. (2016, May 17). Children with and without multiple sclerosis have differences in gut bacteria. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/05/160517083454.htm
Wiley. "Children with and without multiple sclerosis have differences in gut bacteria." ScienceDaily. www.sciencedaily.com/releases/2016/05/160517083454.htm (accessed May 23, 2017).

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