Reference Terms
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COX-2 inhibitor
COX-2 selective inhibitor is a form of Non-steroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain. Selectivity for COX-2 reduces the risk of peptic ulceration, and is the main feature of celecoxib, rofecoxib and other members of this drug class. Cox-2-selectivity does not seem to affect other side-effects of NSAIDs (most notably an increased risk of renal failure), and some results have aroused the suspicion that there might be an increase in the risk for heart attack, thrombosis and stroke by a relative increase in thromboxane. Rofecoxib was taken off the market in 2004 because of these concerns.
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Health & Medicine News
November 6, 2025
Nov. 6, 2025 — A newly identified disorder, MINA syndrome, results from a mutation in the NAMPT protein that deprives motor neurons of energy, leading to severe movement problems. The discovery not only deepens understanding of nerve cell metabolism but also ...
Nov. 6, 2025 — Novo Nordisk’s oral semaglutide 25 mg achieved up to 16.6% weight loss in a landmark study, rivaling injectable Wegovy. The pill also improved cardiovascular risk factors and physical activity levels. With a safety profile consistent with existing ...
Nov. 6, 2025 — Weill Cornell researchers uncovered how free radicals from astrocyte mitochondria can fuel dementia. Using new compounds that target these radicals at their source, they slowed brain inflammation and neuronal damage in mice. The findings reveal a ...
Nov. 6, 2025 — Researchers have created a bioinspired gel that can regenerate tooth enamel by mimicking natural growth processes. The fluoride-free material forms a mineral-rich layer that restores enamel’s strength and structure while preventing decay. It can ...
Nov. 5, 2025 — A Northwestern team transformed a common chemotherapy drug into a powerful, targeted cancer therapy using spherical nucleic acids. The redesign dramatically boosted drug absorption and cancer-killing power while avoiding side effects. This ...
Nov. 5, 2025 — Virginia Tech researchers have shown that memory loss in aging may be reversible. Using CRISPR tools, they corrected molecular disruptions in the hippocampus and amygdala, restoring memory in older rats. Another experiment revived a silenced memory ...
Nov. 5, 2025 — Meditation is widely praised for its mental health benefits, but new research shows that it can also produce unexpected side effects for some people—from anxiety and dissociation to functional impairment. Psychologist Nicholas Van Dam and his team ...
Nov. 5, 2025 — Most U.S. adults don’t realize alcohol raises cancer risk, and drinkers themselves are the least aware. Scientists say targeting these misbeliefs could significantly reduce alcohol-related cancer ...
Nov. 5, 2025 — Researchers discovered how rabies virus exerts massive control over host cells with very few genes. A key viral protein changes shape and binds RNA, allowing it to infiltrate different cellular systems. This adaptability could explain the power of ...
Nov. 4, 2025 — Cockroach infestations don’t just bring creepy crawlers, they fill homes with allergens and bacterial toxins that can trigger asthma and allergies. NC State researchers found that larger infestations meant higher toxin levels, especially from ...
Nov. 4, 2025 — Researchers have, for the first time, estimated how quickly E. coli bacteria can spread between people — and one strain moves as fast as swine flu. Using genomic data from the UK and Norway, scientists modeled bacterial transmission rates and ...
Nov. 4, 2025 — Scientists at Mizzou have identified two small molecules, agmatine and thiamine, that could both reveal and fight glaucoma. Their research shows these compounds are lower in glaucoma patients, suggesting they may serve as early warning markers. Even ...
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Nov. 4, 2025 — A new compound called CMX410 may change the fight against tuberculosis. It targets a weak point in the bacteria’s defenses, even in drug-resistant forms of the disease. Created using a cutting-edge ...
Nov. 4, 2025 — Walking a few thousand steps daily may help hold off Alzheimer’s for years, a Mass General Brigham study found. Even moderate physical activity slowed both cognitive decline and the buildup of ...
Nov. 4, 2025 — A collaboration between Brazilian and German researchers has led to a sunflower-based meat substitute that’s high in protein and minerals. The new ingredient, made from refined sunflower flour, ...
Nov. 4, 2025 — Researchers have discovered a specific set of neurons in the amygdala that can trigger anxiety and social deficits when overactive. By restoring the excitability balance in this brain region, they ...
Nov. 4, 2025 — Using powerful 7-Tesla brain imaging, researchers mapped how the brainstem manages pain differently across the body. They discovered that distinct regions activate for facial versus limb pain, ...
Nov. 4, 2025 — Long-term melatonin use for sleep problems may come with unexpected heart dangers. Researchers found that chronic users were almost twice as likely to die and 3.5 times more likely to be hospitalized ...
Nov. 3, 2025 — UC San Diego researchers combined artificial intelligence with molecular biology to unravel how immune cells in the gut decide between inflammation and healing, a process gone awry in Crohn’s ...
Nov. 3, 2025 — Boston researchers linked nighttime light exposure to greater stress-related brain activity and inflamed arteries, signaling a higher risk of heart disease. The study suggests that artificial light ...
Nov. 3, 2025 — Duke-NUS scientists unveiled BrainSTEM, a revolutionary single-cell map that captures the full cellular diversity of the developing human brain. The project’s focus on dopamine neurons provides ...
Nov. 3, 2025 — Scientists uncovered how the amino acid leucine enhances mitochondrial efficiency by preserving crucial proteins that drive energy production. By downregulating the protein SEL1L, leucine prevents ...