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COX-2 inhibitor
COX-2 selective inhibitor is a form of Non-steroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain. Selectivity for COX-2 reduces the risk of peptic ulceration, and is the main feature of celecoxib, rofecoxib and other members of this drug class. Cox-2-selectivity does not seem to affect other side-effects of NSAIDs (most notably an increased risk of renal failure), and some results have aroused the suspicion that there might be an increase in the risk for heart attack, thrombosis and stroke by a relative increase in thromboxane. Rofecoxib was taken off the market in 2004 because of these concerns.
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June 2, 2026
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June 1, 2026 A long-overlooked organ may hold surprising clues to healthy aging and cancer survival. Researchers at Mass General Brigham used AI to analyze CT scans from tens of thousands of adults and found that people with healthier thymuses—a small ...
May 31, 2026 Scientists at Scripps Research have uncovered a molecular “switch” that appears to fuel the damaging brain inflammation seen in Alzheimer’s disease. They found that a protein called STING becomes chemically altered in a way that keeps the ...
May 31, 2026 Melanoma may not become steadily more dangerous with age as scientists once assumed. In a surprising discovery, researchers found that cancer spread was lowest in young mice, surged in middle-aged mice, and then dropped again in very old mice. The ...
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May 31, 2026 A new study suggests fish oil may help reduce insulin resistance even in people who aren't obese. In diabetic rats, omega-3 supplementation improved blood sugar levels, cholesterol, and inflammation by shifting immune cells into a more ...
May 30, 2026 A new study suggests melatonin supplements may help night shift workers boost their body's DNA repair processes, potentially offsetting some of the damage linked to working overnight. The findings ...
May 30, 2026 A specially formulated tomato-soy juice packed with natural plant compounds may help calm inflammation linked to obesity, according to a new clinical study. Healthy adults with obesity who drank the juice daily for four weeks saw significant ...
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May 29, 2026 Scientists at Stanford may have uncovered a hidden reason our brains decline with age. Studying the ultra-short-lived turquoise killifish, researchers discovered that the cellular machinery ...
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