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COX-2 inhibitor
COX-2 selective inhibitor is a form of Non-steroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain. Selectivity for COX-2 reduces the risk of peptic ulceration, and is the main feature of celecoxib, rofecoxib and other members of this drug class. Cox-2-selectivity does not seem to affect other side-effects of NSAIDs (most notably an increased risk of renal failure), and some results have aroused the suspicion that there might be an increase in the risk for heart attack, thrombosis and stroke by a relative increase in thromboxane. Rofecoxib was taken off the market in 2004 because of these concerns.
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Health & Medicine News
August 26, 2026
Aug. 26, 2026 Moderate calorie restriction lowered an immune protein called C3 that appears to help drive chronic inflammation as the body ages. Blocking the same protein reduced age related inflammation in mice, ...
Aug. 26, 2026 Britain’s postwar sugar rationing created a rare natural experiment that let researchers examine how early sugar exposure might affect health decades later. People who experienced more rationing during their first 1,000 days had lower rates of ...
Aug. 26, 2026 A compound found in turmeric may help protect blood vessels from some of the damage caused by Type 1 diabetes. In rats, curcumin reduced inflammation, improved cellular signaling, and restored vascular health to levels resembling those of ...
Aug. 26, 2026 A wavelength of light largely missing from indoor LEDs may play an important role in protecting developing eyes from nearsightedness. Researchers found that indigo light completely prevented myopia in tree shrews, whose eyes share important ...
Aug. 26, 2026 Early-life stress may physically alter how DNA is packaged in the brain, leaving stress-related genes primed to activate more easily years later. In mice, researchers were able to block this effect, preventing the heightened anxiety and stress ...
Aug. 25, 2026 A low-carb diet may raise LDL cholesterol much more sharply in people who are genetically predisposed to high cholesterol, particularly when they consume lots of saturated fat. The findings could help explain why people following seemingly similar ...
Aug. 25, 2026 Older adults who received the Shingrix shingles vaccine were 24% less likely to be diagnosed with dementia over four years in a study of more than 500,000 people. Researchers estimate the difference could amount to roughly one dementia case ...
Aug. 25, 2026 Researchers have found a way to supercharge natural killer cells, powerful immune cells that can attack cancer, so they can penetrate solid tumors and keep fighting once inside. In mice, these ...
Aug. 25, 2026 A major study found that adults with depression show disrupted production of new neurons in the hippocampus, potentially weakening the brain’s ability to separate new experiences from painful memories. The researchers also identified broad ...
Aug. 25, 2026 People who reach 110 and beyond appear to have unusually large numbers of rare immune cells capable of killing abnormal cells. These CD4 cytotoxic T cells became more common with age and often expanded into large groups of nearly identical cells, ...
Aug. 24, 2026 Common medications may reshape the gut microbiome long after the last dose is taken. In a study of more than 2,500 people, researchers found lasting microbial changes linked not only to antibiotics, but also to antidepressants, beta-blockers, ...
Aug. 24, 2026 Backyard bird feeders could become unexpected hotspots for H5N1 as Australia’s bird flu outbreak spreads, bringing species together in ways that rarely occur naturally. Experts say stopping feeding is safest, while smaller amounts of food, no ...
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Aug. 24, 2026 Both too little and too much sleep may be linked to faster aging throughout the body. Researchers analyzing 23 biological aging clocks found the lowest aging levels among people sleeping about 6.4 to ...
Aug. 23, 2026 Gut bacteria can transform nitrate and plant-based iron from vegetables and other foods into protective molecules that may benefit the heart and metabolism. In experimental models, higher levels of ...
Aug. 23, 2026 Researchers have uncovered a possible reason why the Alzheimer’s risk gene APOE4 can disrupt the brain long before memory problems begin. In mice, ...
Aug. 23, 2026 Researchers have found a way to slash the processing time for 3D-printed zirconia crowns from as much as 100 hours to under 30 minutes. The advance could eventually let dentists print strong, ...
Aug. 23, 2026 Researchers have used AI to uncover the DNA signature of a key genetic “switch” involved in turning genes on. After analyzing about 500,000 DNA sequences, the model identified the initiator in ...
Aug. 23, 2026 A decades-old compound may point to a new way of treating obesity by making the body burn more energy rather than simply reducing appetite. In mice, TOFA increased energy use by as much as 18%, ...
Aug. 23, 2026 A massive analysis involving more than 100 million people has found strong links between recreational drug use and stroke, including among younger adults. Cocaine was associated with nearly double ...
Aug. 23, 2026 Older adults with mild cognitive impairment and sleep problems who took at least 5,000 IU of vitamin D daily scored more than 13% higher on a cognitive test than those taking none. The preliminary ...
Aug. 22, 2026 Greenland sharks may live for 400 years without suffering the kind of retinal decline normally associated with aging. Researchers found healthy eye tissue and active proteins specially adapted for ...
Aug. 22, 2026 Mice that developed compulsive drinking after alcohol abstinence showed more than double the activity in a brain region associated with stress and addiction. Because the signal appeared before they ...