Science News
from research organizations

Dynamic DNA polymers can be reversed using biocompatible techniques

Date:
May 17, 2016
Source:
Penn State
Summary:
DNA-based straight and branched polymers or nanomaterials that can be created and dissolved using biocompatible methods are now possible thanks to the work of biomedical engineers.
Share:
FULL STORY

DNA nanotrees can grow and decompose via molecular controls at standard physiological conditions. A nanotree made of DNA can be reversed under standard physiological conditions without burning, according to a new study by a team of Penn State biomedical engineers.
Credit: Penn State

DNA-based straight and branched polymers or nanomaterials that can be created and dissolved using biocompatible methods are now possible thanks to the work of Penn State biomedical engineers.

Synthetic polymers may lead to advances in a broad range of biological and biomedical applications such as drug delivery, molecular detection and bioimaging.

"Achieving reversibility of synthetic polymers and nanomaterials has been a long-standing dream for many biomedical engineers," said Yong Wang, associate professor of biomedical engineering. "Scientists want to see these polymers reverse or disappear when we are finished with them, but that often involves the use of high temperatures and chemical solvents. With that idea in mind, the aim of our study was to create synthetic polymers that would decompose without the use of harsh elements or increased stress. In principle, the polymers could be further tuned to synthesize a diverse array of nanomaterials or bulk materials."

To assemble the dynamic polymers, researchers linked DNA initiators -- straight DNA strands with a single binding domain -- to two DNA monomers with multiple domains. The bonded molecules formed a linear double-stranded DNA structure with a separate and functional side group. The researchers then created a trigger molecule that attached to the side group and initiated a "reverse without the involvement of any non-physiological factors," according to a recent article in Angewandte Chemie International Edition.

The researchers also showed that branched polymers responded to the same technique.

Branched polymers synthesized with a straight polymer and two DNA monomers yielded two functional side groups with the ability to reverse when induced by two molecular triggers.

The researchers performed preliminary testing of the model in water, with subsequent testing conducted on synthetic antibodies. Antibody trials proved that growth and depolymerization of straight and branched polymers were also possible on the microparticle surface and in the extracellular matrix.

Wang and his team are hopeful that by uniting the polymers with various molecules and materials, their findings will hold value for a number of wide-ranging applications.


Story Source:

Materials provided by Penn State. Note: Content may be edited for style and length.


Journal Reference:

  1. Niancao Chen, Xuechen Shi, Yong Wang. Molecularly Regulated Reversible DNA Polymerization. Angewandte Chemie International Edition, 2016; DOI: 10.1002/anie.201601008

Cite This Page:

Penn State. "Dynamic DNA polymers can be reversed using biocompatible techniques." ScienceDaily. ScienceDaily, 17 May 2016. <www.sciencedaily.com/releases/2016/05/160517191855.htm>.
Penn State. (2016, May 17). Dynamic DNA polymers can be reversed using biocompatible techniques. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/05/160517191855.htm
Penn State. "Dynamic DNA polymers can be reversed using biocompatible techniques." ScienceDaily. www.sciencedaily.com/releases/2016/05/160517191855.htm (accessed May 23, 2017).

RELATED STORIES