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Are there ethnic differences in cognitive outcomes based on BP targets?

Date:
August 21, 2017
Source:
The JAMA Network Journals
Summary:
A new article investigates how various blood pressure targets for older patients treated for hypertension were associated with cognitive function and if ethnic differences existed in long-term cognitive outcomes.
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A new article published by JAMA Neurology investigates how various blood pressure targets for older patients treated for hypertension were associated with cognitive function and if racial differences existed in long-term cognitive outcomes.

The Eighth Joint National Committee (JNC-8) recommended treating systolic blood pressure (SBP) to a target below 150 mm Hg in older adults while the Systolic Blood Pressure Intervention Trial (SPRINT) suggested a SBP level lower than 120 mm Hg decreases cardiovascular event rates. The association of discordant SBP targets with cognition and differences by race has not been systematically evaluated in the same population.

The study by Ihab Hajjar, M.D., M.S., of the Emory School of Medicine, Atlanta, and coauthors included 1,657 cognitively intact older adults ages 70 to 79 who were receiving treatment for hypertension and who were studied for a decade from 1997 to 2007.

The authors report a greater decline in cognitive scores was associated with patients with SBP of 150 mm Hg or higher and less decline in those with SBP of 120 mm HG or lower. The study findings suggest a lower SBP target for black patients may be associated with greater cognitive benefit.

The study acknowledges limitations, including the use of observational data with no randomization.

"This analysis of 10-year data from older adults receiving treatment for hypertension in the Health ABC study suggests that lower SBP levels are associated with greater cognitive protection. The lower targets may offer greater protection for older black adults with hypertension. Future guidelines need to consider this racial difference when reviewing or providing recommendations for management of hypertension," the article concludes.


Story Source:

Materials provided by The JAMA Network Journals. Note: Content may be edited for style and length.


Journal Reference:

  1. Ihab Hajjar, Kristine J. Rosenberger, Ambar Kulshreshtha, Hilsa N. Ayonayon, Kristine Yaffe, Felicia C. Goldstein. Association of JNC-8 and SPRINT Systolic Blood Pressure Levels With Cognitive Function and Related Racial Disparity. JAMA Neurology, 2017; DOI: 10.1001/jamaneurol.2017.1863

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The JAMA Network Journals. "Are there ethnic differences in cognitive outcomes based on BP targets?." ScienceDaily. ScienceDaily, 21 August 2017. <www.sciencedaily.com/releases/2017/08/170821122759.htm>.
The JAMA Network Journals. (2017, August 21). Are there ethnic differences in cognitive outcomes based on BP targets?. ScienceDaily. Retrieved April 12, 2024 from www.sciencedaily.com/releases/2017/08/170821122759.htm
The JAMA Network Journals. "Are there ethnic differences in cognitive outcomes based on BP targets?." ScienceDaily. www.sciencedaily.com/releases/2017/08/170821122759.htm (accessed April 12, 2024).

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