New! Sign up for our free email newsletter.
Science News
from research organizations

New mechanism points the way to breaking ribosome antibiotic resistance

Date:
September 28, 2017
Source:
University of Groningen
Summary:
Research groups reveal a novel mechanism of ribosome dimerization in the bacterium Lactococcus lactis using cryo-electron microscopy. As this dimerization renders ribosomes more resistant to antibiotics, this study provides the necessary structural basis to design new generations of antibiotics.
Share:
FULL STORY

Antibiotics are the most common medication used to treat microbial infections. Many antibiotics target intracellular bacterial ribosomes -- cellular factories that synthesize proteins -- which are essential for bacterial survival and proliferation. When bacteria have an excess of protein synthesis activity they stall the ribosomes in an inactive dimeric complex (i.e. two copies of ribosomes interact with each other). This so-called hibernating ribosome complex is more resistant to antibiotics.

In a collaborative effort, research groups from the Groningen Biomolecular Sciences and Biotechnology Institute of the University of Groningen led by Egbert Boekema, Bert Poolman and Albert Guskov revealed a novel mechanism of ribosome dimerization in the bacterium Lactococcus lactis using cryo-electron microscopy. The peculiarity of the mechanism they describe is that it involves a single protein, named HPFlong, which is capable to dimerize on its own and then pull two copies of ribosomes together. The dimeric state of the ribosome is no longer capable of synthesizing new proteins.

This hibernation mechanism is in a stark contrast with previous studies done in another microorganism, Escherichia coli. However based on a phylogenetic analysis of the amino acid sequence of HPFlong, the researchers conclude that the mechanism they propose is more widely spread, since protein HPFlong is present in nearly all known bacteria. This study provides the necessary structural basis to design new generations of antibiotics targeting hibernating ribosomes.


Story Source:

Materials provided by University of Groningen. Note: Content may be edited for style and length.


Journal Reference:

  1. Linda E. Franken, Gert T. Oostergetel, Tjaard Pijning, Pranav Puri, Valentina Arkhipova, Egbert J. Boekema, Bert Poolman, Albert Guskov. A general mechanism of ribosome dimerization revealed by single-particle cryo-electron microscopy. Nature Communications, 2017; 8 (1) DOI: 10.1038/s41467-017-00718-x

Cite This Page:

University of Groningen. "New mechanism points the way to breaking ribosome antibiotic resistance." ScienceDaily. ScienceDaily, 28 September 2017. <www.sciencedaily.com/releases/2017/09/170928084754.htm>.
University of Groningen. (2017, September 28). New mechanism points the way to breaking ribosome antibiotic resistance. ScienceDaily. Retrieved April 19, 2024 from www.sciencedaily.com/releases/2017/09/170928084754.htm
University of Groningen. "New mechanism points the way to breaking ribosome antibiotic resistance." ScienceDaily. www.sciencedaily.com/releases/2017/09/170928084754.htm (accessed April 19, 2024).

Explore More

from ScienceDaily

RELATED STORIES