New! Sign up for our free email newsletter.
Science News
from research organizations

Constructing new tissue shapes with light

Researchers guide the shape of cells and tissues with optogenetics

Date:
June 18, 2018
Source:
European Molecular Biology Laboratory
Summary:
Constructing biological tissues, such as skin, muscle, or bone, in customized shapes is now one step closer. Researchers have succeeded in guiding the folding and thus shape of tissues with optogenetics: a technique to control protein activity with light.
Share:
FULL STORY

Constructing biological tissues, such as skin, muscle, or bone, in customized shapes is now one step closer. Researchers at EMBL have succeeded in guiding the folding and thus shape of tissues with optogenetics: a technique to control protein activity with light. Nature Communications publishes their results, with implications for regenerative medicine, on 18 June.

The changing of tissue shapes in an embryo is essential for healthy development. Stefano De Renzis and his group members at EMBL are interested in the mechanisms behind these shape transitions, also called morphogenesis. They use optogenetics -- a technique providing precise light-mediated control of protein activity -- to study changes in tissue shapes.

Uncoupling the link between shape and function

In the current paper, Emiliano Izquierdo, Theresa Quinkler, and Stefano De Renzis used optogenetics to reconstruct epithelial folding: a fundamental process during development, where cells move inwards and fold into the embryo, eventually giving rise to internal tissues like muscles, for example. Remarkably, they achieved this in cells that normally do not undergo this process. De Renzis, who led the study: "We've uncoupled the link between the shape and function of a cell. This allows us to, for the first time, built tissues in certain shape without affecting the cell's expertise."

Precise control

"The great thing about using optogenetics to guide morphogenesis is that it is a very precise technique," says Emiliano Izquierdo, first author of the study. "We were able to define various shapes, and by alternating the timing and strength of illumination, we could control how far the cells folded inwards."

From fruit fly to the clinic?

The research was done in developing fruit flies, but since epithelial folding is a conserved process across evolution, De Renzis expects these methods to also be applicable in other organisms and ex vivo stem cell culture systems. In that case, optogenetics could be an ideal technique for reconstructing and directing tissue development, which could be used to (re)build artificial tissues in regenerative medicine.


Story Source:

Materials provided by European Molecular Biology Laboratory. Original written by Iris Kruijen. Note: Content may be edited for style and length.


Journal Reference:

  1. Emiliano Izquierdo, Theresa Quinkler, Stefano De Renzis. Guided morphogenesis through optogenetic activation of Rho signalling during early Drosophila embryogenesis. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-04754-z

Cite This Page:

European Molecular Biology Laboratory. "Constructing new tissue shapes with light." ScienceDaily. ScienceDaily, 18 June 2018. <www.sciencedaily.com/releases/2018/06/180618102624.htm>.
European Molecular Biology Laboratory. (2018, June 18). Constructing new tissue shapes with light. ScienceDaily. Retrieved July 18, 2024 from www.sciencedaily.com/releases/2018/06/180618102624.htm
European Molecular Biology Laboratory. "Constructing new tissue shapes with light." ScienceDaily. www.sciencedaily.com/releases/2018/06/180618102624.htm (accessed July 18, 2024).

Explore More

from ScienceDaily

RELATED STORIES