Normal variations in thyroid function may be linked to atrial fibrillation risk
- Date:
- January 23, 2019
- Source:
- Vanderbilt University Medical Center
- Summary:
- A study has strengthened the link between thyroid function and atrial fibrillation (AF), an irregular heart rhythm that increases the risk of stroke and other heart-related complications.
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A study by researchers at Vanderbilt University Medical Center has strengthened the link between thyroid function and atrial fibrillation (AF), an irregular heart rhythm that increases the risk of stroke and other heart-related complications.
The phenome-wide association study scanned the medical records of more than 37,000 people for an association between genetically determined variation in thyroid stimulating hormone levels (a measure of thyroid function) and AF risk.
Previous observational studies have found that subclinical hyperthyroidism, an overactive thyroid which does not meet the clinical threshold for diagnosis or treatment, nevertheless can increase the risk of AF. But whether to treat subclinical hypo- or hyperthyroidism to reduce AF risk remains a matter of debate in the medical community.
The current study, published today in the journal JAMA Cardiology, found that genetically determined variations in thyroid function, even those which fall within a physiologically accepted "normal" range, still can increase the risk for AF.
The decision to treat subclinical thyroid disease should account for this new evidence, as "antithyroid medications to treat hyperthyroidism may reduce AF risk (while) thyroid hormone replacement for hypothyroidism (low thyroid function) may increase AF risk," the researchers concluded.
Story Source:
Materials provided by Vanderbilt University Medical Center. Note: Content may be edited for style and length.
Journal Reference:
- Joe-Elie Salem, M. Benjamin Shoemaker, Lisa Bastarache, Christian M. Shaffer, Andrew M. Glazer, Brett Kroncke, Quinn S. Wells, Mingjian Shi, Peter Straub, Gail P. Jarvik, Eric B. Larson, Digna R. Velez Edwards, Todd L. Edwards, Lea K. Davis, Hakon Hakonarson, Chunhua Weng, David Fasel, Bjorn C. Knollmann, Thomas J. Wang, Joshua C. Denny, Patrick T. Ellinor, Dan M. Roden, Jonathan D. Mosley. Association of Thyroid Function Genetic Predictors With Atrial Fibrillation. JAMA Cardiology, 2019; DOI: 10.1001/jamacardio.2018.4615
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