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Active ingredient of aconite root against peripheral neuropathic pain is identified as neoline

Date:
April 10, 2019
Source:
Nagoya City University
Summary:
Aconite root is used in East Asian traditional medicines to treat pain. Since its toxicity, it is used after heat-processing for detoxifying. The present study revealed that processed aconite root could relief neuropathic pain in murine peripheral neuropathy model induced by oxaliplatin, paclitaxel, or partial ligation of the sciatic nerve (Seltzer model), and identified that its active ingredient is not benzoylmesaconine, a degraded compound of toxic mesaconitine, but neoline, a stable compound by detoxifying heat-processing.
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Aconite root is used in East Asian traditional medicines to treat pain. Since its toxicity, it is used after heat-processing for detoxifying. The present study revealed that processed aconite root could relief neuropathic pain in murine peripheral neuropathy model induced by oxaliplatin, paclitaxel, or partial ligation of the sciatic nerve (Seltzer model), and identified that its active ingredient is not benzoylmesaconine, a degraded compound of toxic mesaconitine, but neoline, a stable compound by detoxifying heat-processing.

The root of Aconitum carmichaeli (Ranunculaceae), is a crude drug used in traditional Chinese or Japanese kampo medicine to treat pain associated with coldness. Since aconite root is highly toxic, processing methods for detoxifying have been developed, and toxic ingredients such as aconitine and mesaconitine degrade into benzoylaconine and benzoylmesaconitine by heat-processing. Although the analgesic activity and the toxicity of mesaconitine is strong, those of benzoylmesaconitine are about 1,000-fold weaker than mesaconitine. However, in traditional medicine, processed aconite root has been used for various pain in clinic.

The present study revealed that processed aconite root could relief neuropathic pain in murine peripheral neuropathy model induced by intraperitoneal injection of oxaliplatin, paclitaxel, or the partial ligation of the sciatic nerve (Seltzer model), and identified that its active ingredient is neoline. In the plasma samples of rats treated with processed aconite root, higher concentrations of benzoylmesaconine and neoline were apparent among Aconitum alkaloids. Subcutaneous injection of benzoylmesaconine did not attenuate the hyperalgesia in mice models. Neoline is a stable compound by heat-processing of aconite root. The present results indicate that processed aconite root and its active ingredient, neoline, are promising agents for the alleviation of neuropathic pain.


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Materials provided by Nagoya City University. Note: Content may be edited for style and length.


Journal Reference:

  1. Yohei Tanimura, Masato Yoshida, Masahiro Ohsawa, Toshiaki Makino. Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats. Journal of Ethnopharmacology, 2019; 111859 DOI: 10.1016/j.jep.2019.111859

Cite This Page:

Nagoya City University. "Active ingredient of aconite root against peripheral neuropathic pain is identified as neoline." ScienceDaily. ScienceDaily, 10 April 2019. <www.sciencedaily.com/releases/2019/04/190410102306.htm>.
Nagoya City University. (2019, April 10). Active ingredient of aconite root against peripheral neuropathic pain is identified as neoline. ScienceDaily. Retrieved December 12, 2024 from www.sciencedaily.com/releases/2019/04/190410102306.htm
Nagoya City University. "Active ingredient of aconite root against peripheral neuropathic pain is identified as neoline." ScienceDaily. www.sciencedaily.com/releases/2019/04/190410102306.htm (accessed December 12, 2024).

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