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Surgery before pregnancy linked to higher risk of opioid withdrawal in babies

Use of opioids to control post-op pain can lead to dependency

Date:
July 15, 2019
Source:
University of Montreal Hospital Research Centre (CRCHUM)
Summary:
Babies whose mothers underwent surgery before pregnancy have an increased risk of opioid withdrawal symptoms at birth, according to a new study.
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Babies whose mothers underwent surgery before pregnancy have an increased risk of opioid withdrawal symptoms at birth, according to a new study done by Dr. Nathalie Auger, researcher at the University of Montreal Hospital Research Centre (CRCHUM), and published in the Canadian Medical Association Journal.

"Use of opioids for pain control after surgery may increase the risk of opioid dependence in women and withdrawal in their newborns," said the study's lead author, Dr Auger, also a professor at the University of Montreal's School of Public Health.

"We found that mothers who had surgery before pregnancy had 1.6 times the risk of neonatal abstinence syndrome -- that is, opioid withdrawal symptoms in their future newborns -- perhaps because opioid use continues after surgery."

The large study included data on almost 2.2 million births in Quebec between 1989 and 2016. Of these, 2,346 newborns had neonatal abstinence syndrome, including 1,052 who had mothers who underwent prepregnancy surgery (14.9 per 10,000 babies) compared with 1,294 babies (8.8 per 10,000) born to mothers who did not have surgery.

Multiple surgeries, younger age at surgery, longer time between surgery and pregnancy, and cardiovascular, thoracic, urologic, or neurosurgery were associated with the largest risk of neonatal abstinence syndrome. There was also a strong association with general anesthesia, perhaps because this type of anesthesia is used in more complex surgeries, which can require longer use and higher dosage of pain relievers.

"Physicians have the potential to prevent neonatal abstinence syndrome with careful postoperative pain management in young women," Auger said. "Opioids continue to be overprescribed, despite calls to optimize postsurgical pain control through improvement of surgical guidelines and use of multipronged approaches with nonopioid painkillers or local anesthetics."

"Limiting postoperative opioid exposure, reducing overprescribing, and screening for opioid use in pregnant women who have had previous surgery may help reduce the risk of neonatal abstinence syndrome," she added.


Story Source:

Materials provided by University of Montreal Hospital Research Centre (CRCHUM). Note: Content may be edited for style and length.


Journal Reference:

  1. Nathalie Auger, Nancy Low, François M. Carrier, Aimina Ayoub, Thuy Mai Luu. Maternal prepregnancy surgery and risk of neonatal abstinence syndrome in future newborns: a longitudinal cohort study. Canadian Medical Association Journal, 2019; 191 (28): E779 DOI: 10.1503/cmaj.181519

Cite This Page:

University of Montreal Hospital Research Centre (CRCHUM). "Surgery before pregnancy linked to higher risk of opioid withdrawal in babies." ScienceDaily. ScienceDaily, 15 July 2019. <www.sciencedaily.com/releases/2019/07/190715075438.htm>.
University of Montreal Hospital Research Centre (CRCHUM). (2019, July 15). Surgery before pregnancy linked to higher risk of opioid withdrawal in babies. ScienceDaily. Retrieved October 14, 2024 from www.sciencedaily.com/releases/2019/07/190715075438.htm
University of Montreal Hospital Research Centre (CRCHUM). "Surgery before pregnancy linked to higher risk of opioid withdrawal in babies." ScienceDaily. www.sciencedaily.com/releases/2019/07/190715075438.htm (accessed October 14, 2024).

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