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Cracking the code for hookworm infestation

Date:
February 12, 2020
Source:
Monash University
Summary:
Monash University researchers have uncovered a key way that hookworms evade the immune system - providing new hope in the search for a vaccine.
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Hookworms infect nearly around 700 million people in the world, mostly in countries where sanitation is poor, and people often walk barefoot.

The body's immune system is critical to attacking the hookworm, but these parasites are masters of escape and individuals typically remain infected throughout their lifetime, often resulting in death or complications stemming from anaemia.

Monash University researchers have uncovered a key way that hookworms evade the immune system -- providing new hope in the search for a vaccine.

Importantly, the researchers, led by Professor Nicola Harris from Monash University's Central Clinical School, may have discovered why people are unable to kill hookworms.

The research, published today in Cell Host and Microbe, shows that a type of immune cell in the blood, called neutrophils, can kill hookworms by releasing neutrophil extracellular traps (NETs) made up of toxin-coated DNA.

However, the hookworm has developed a way to sense what the neutrophil is doing, releasing an enzyme that degrades the DNA backbone of the trap, allowing the hookworm to remain and continue infecting its host.

Professor Harris and her colleagues suggest the NETS created by the neutrophils could kill the worm providing people living in hookworm prone areas by boosting much needed immunity.

Professor Harris says that the discovery could form the basis of a vaccine to achieve this goal.

"No protective vaccines currently exist, and their successful development requires an improved understanding of both the body's immune response and the biology of these worm-like pests known as nematodes," Professor Harris said.

"We have found that hookworms have evolved a previously unrecognised evasion mechanism to degrade the immune system's response, thus persistently infecting their hosts.

"We may now be able to look at new vaccination approaches that target the enzyme secreted by the hookworm parasite to alleviate infestation and to decrease the likelihood of reinfection."


Story Source:

Materials provided by Monash University. Original written by Courtney Karayannis. Note: Content may be edited for style and length.


Journal Reference:

  1. Tiffany Bouchery, Mati Moyat, Javier Sotillo, Solomon Silverstein, Beatrice Volpe, Gillian Coakley, Theodora-Dorita Tsourouktsoglou, Luke Becker, Kathleen Shah, Manuel Kulagin, Romain Guiet, Mali Camberis, Alfonso Schmidt, Arne Seitz, Paul Giacomin, Graham Le Gros, Venizelos Papayannopoulos, Alex Loukas, Nicola L. Harris. Hookworms Evade Host Immunity by Secreting a Deoxyribonuclease to Degrade Neutrophil Extracellular Traps. Cell Host & Microbe, 2020; 27 (2): 277 DOI: 10.1016/j.chom.2020.01.011

Cite This Page:

Monash University. "Cracking the code for hookworm infestation." ScienceDaily. ScienceDaily, 12 February 2020. <www.sciencedaily.com/releases/2020/02/200212131502.htm>.
Monash University. (2020, February 12). Cracking the code for hookworm infestation. ScienceDaily. Retrieved March 28, 2024 from www.sciencedaily.com/releases/2020/02/200212131502.htm
Monash University. "Cracking the code for hookworm infestation." ScienceDaily. www.sciencedaily.com/releases/2020/02/200212131502.htm (accessed March 28, 2024).

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