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New discovery could lead to therapies for patients with Duchenne muscular dystrophy

Date:
April 14, 2021
Source:
University of California - Irvine
Summary:
A new study reveals how chronic inflammation promotes muscle fibrosis, which could inform the development of new therapies for patients suffering from Duchenne muscular dystrophy (DMD), a fatal muscle disease.
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A new study, led by the University of California, Irvine (UCI), reveals how chronic inflammation promotes muscle fibrosis, which could inform the development of new therapies for patients suffering from Duchenne muscular dystrophy (DMD), a fatal muscle disease.

Titled, "A Stromal Progenitor and ILC2 Niche Promotes Muscle Eosinophilia and Fibrosis-Associated Gene Expression," the study was published today in Cell Reports. Chronic inflammation is a major pathological process contributing to the progression and severity of several degenerative disorders, including Duchenne muscular dystrophy (DMD). Studies directed at establishing a causal link between muscular dystrophy and muscle inflammation have revealed a complex dysregulation of the immune response to muscle damage.

During muscular dystrophy, chronic activation of innate immunity causes scarring of skeletal muscle, or fibrosis, compromising motor function. How immunity is linked to the molecular and cellular regulation of muscle fibrosis was not well defined, until now.

"In our study we found the interaction between two types of cells -- a novel stromal progenitor, which is similar to a stem cell, and group 2 innate lymphoid cells (ILC2), which are a type of immune cell that reside in skeletal muscle -- promotes the invasion of white blood cells in muscle. This condition is associated with the elevation of genes that promote muscle tissue scarring found in DMD," said lead author Jenna Kastenschmidt, PhD, an assistant specialist in the UCI School of Medicine Department of Physiology & Biophysics.

The new study not only reveals the interaction of cells contributing to DMD, but it illuminates how muscle eosinophilia is regulated. Eosinophils are white blood cells that infiltrate dystrophic muscle causing fibrosis. In this study, researchers found that eosinophils were elevated in DMD muscle compared to control patients. In addition, researchers found the deletion of ILC2s in dystrophic mice mitigated muscle eosinophilia, reducing the expression of genes associated with muscle fibrosis. These findings contribute to the understanding of the complex regulation of muscle inflammation and fibrosis during muscular dystrophy.

"By further defining the interaction between skeletal muscle-resident immune and stromal cells, we can better understand how chronic inflammation promotes muscle fibrosis and, more importantly, we can facilitate development of novel therapies for DMD," said senior author Armando Villalta, PhD, assistant professor in UCI's Department of Physiology & Biophysics.

Ongoing work from Villalta's lab continues to focus on how distinct facets of the immune system regulate DMD pathogenesis and how these processes influence the efficacy and long-term stability of gene replacement therapy.


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Materials provided by University of California - Irvine. Note: Content may be edited for style and length.


Journal Reference:

  1. Jenna M. Kastenschmidt, Gerald Coulis, Philip K. Farahat, Phillip Pham, Rodolfo Rios, Therese T. Cristal, Ali H. Mannaa, Rachel E. Ayer, Rayan Yahia, Archis A. Deshpande, Brandon S. Hughes, Adam K. Savage, Carlee R. Giesige, Scott Q. Harper, Richard M. Locksley, Tahseen Mozaffar, S. Armando Villalta. A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression. Cell Reports, 2021; 35 (2): 108997 DOI: 10.1016/j.celrep.2021.108997

Cite This Page:

University of California - Irvine. "New discovery could lead to therapies for patients with Duchenne muscular dystrophy." ScienceDaily. ScienceDaily, 14 April 2021. <www.sciencedaily.com/releases/2021/04/210414154914.htm>.
University of California - Irvine. (2021, April 14). New discovery could lead to therapies for patients with Duchenne muscular dystrophy. ScienceDaily. Retrieved March 28, 2024 from www.sciencedaily.com/releases/2021/04/210414154914.htm
University of California - Irvine. "New discovery could lead to therapies for patients with Duchenne muscular dystrophy." ScienceDaily. www.sciencedaily.com/releases/2021/04/210414154914.htm (accessed March 28, 2024).

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