New! Sign up for our free email newsletter.
Science News
from research organizations

Breakthrough identification of proteins necessary for muscle regeneration

Clears the way for drug development for skeletal muscle diseases

Date:
December 20, 2021
Source:
University of Houston
Summary:
A researcher has identified the proteins necessary for efficient regeneration of skeletal muscles after acute injury and in Duchenne Muscular Dystrophy (DMD) clearing the way for drug development for skeletal muscle diseases.
Share:
FULL STORY

A researcher at the University of Houston College of Pharmacy has identified the proteins necessary for efficient regeneration of skeletal muscles after acute injury and in Duchenne Muscular Dystrophy (DMD). Ashok Kumar, Else and Philip Hargrove Endowed Professor of Pharmacological and Pharmaceutical Sciences, is reporting his findings in eLife.

Skeletal muscles, which connect your bones and allow you to move, contain 50-75% of all the body's proteins. Not only are they the most abundant and dynamic tissue of the human body essential for posture, locomotion and breathing, but they also control the body's entire metabolism.

So, when skeletal muscles get hurt or injured either through trauma or degenerative disease, it can become complicated.

"We identified that the IRE1 protein -- localized on the membrane of endoplasmic reticulum (the organelle that is involved in the production, folding and quality control of proteins) and XBP1 protein are important for efficient regeneration of skeletal muscle after injury and in DMD," reports Kumar. Anirban Roy, research assistant professor of pharmacology, is the paper's first author.

Understanding the mechanisms of skeletal muscle regeneration is essential for the development of new therapeutics aimed at treating various genetic and acquired degenerative muscle disorders.

"We found that skeletal muscle repair was considerably diminished in models in which IRE1 or XBP1 protein was specifically removed from skeletal muscle. These proteins support skeletal muscle regeneration through enhancing the proliferation of resident muscle stem cells. Deletion of IRE1 in skeletal muscle reduces abundance of muscle stem cells and exaggerates muscular dystrophy phenotype," said Kumar.

Ongoing studies in the Kumar laboratory are investigating whether recently developed highly specific pharmacological activators of IRE1 and XBP1 can improve skeletal muscle regeneration after acute injury and other muscle degenerative diseases.

"The research work has enormous scope for drug development for skeletal muscle diseases," said Kumar.


Story Source:

Materials provided by University of Houston. Original written by Laurie Fickman. Note: Content may be edited for style and length.


Journal Reference:

  1. Anirban Roy, Meiricris Tomaz da Silva, Raksha Bhat, Kyle R Bohnert, Takao Iwawaki, Ashok Kumar. The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism. eLife, 2021; 10 DOI: 10.7554/eLife.73215

Cite This Page:

University of Houston. "Breakthrough identification of proteins necessary for muscle regeneration." ScienceDaily. ScienceDaily, 20 December 2021. <www.sciencedaily.com/releases/2021/12/211220144957.htm>.
University of Houston. (2021, December 20). Breakthrough identification of proteins necessary for muscle regeneration. ScienceDaily. Retrieved July 17, 2024 from www.sciencedaily.com/releases/2021/12/211220144957.htm
University of Houston. "Breakthrough identification of proteins necessary for muscle regeneration." ScienceDaily. www.sciencedaily.com/releases/2021/12/211220144957.htm (accessed July 17, 2024).

Explore More

from ScienceDaily

RELATED STORIES