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Groundbreaking research unveils genetic characteristics and improved prognosis of triple negative apocrine carcinoma

Date:
September 13, 2023
Source:
Ulsan National Institute of Science and Technology(UNIST)
Summary:
A research team has led a groundbreaking study that delves into the exploration of triple-negative apocrine carcinoma.
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Breast cancer research takes a significant stride forward as Professor Semin Lee and his research team from the Department of Biomedical Engineering at UNIST, in collaboration with Professor Ji-Yeon Kim and Professor Young-Hyuck Im from the Division of Hematology-Oncology at Samsung Medical Center in Seoul, delves into the exploration of triple negative apocrine carcinoma. This rare breast cancer subtype has garnered attention due to its unique genetic characteristics and improved prognosis when compared to other forms of triple-negative breast cancer (TNBC).

Triple negative apocrine carcinoma accounts for only 1-4% of all breast cancers. While it falls under the category of TNBC, which is characterized by the absence of hormone receptors and epidermal growth factor receptors, this particular subtype exhibits a more favorable prognosis than other TNBC subtypes. However, due to limited analysis studies on triple negative apocrine carcinoma, treatment criteria have remained ambiguous.

In their study, the research team employed advanced molecular biological methods to conduct multi-omics analyses -- integrating genetic information and RNA molecules -- to unravel novel insights into this rare form of breast cancer.

The findings revealed distinct genomic characteristics that impact the prognosis for patients with triple negative apocrine carcinoma. The researchers identified four to five unique subtypes within breast cancer based on gene expression profiles. Notably, patients with triple-negative apocrine carcinoma exhibited similarities to Luminal A -- a subtype associated with better prognostic outcomes. The study confirmed an impressive five-year disease-free survival rate for these patients at 92.2%, significantly higher than those diagnosed with other types of TNBC (59.1%).

"This research has the potential to guide treatment decisions regarding adjuvant chemotherapy after surgery and predict patient survival outcomes," explained Sabin Park (Department of Biomedical Engineering, UNIST), first author of the study, while emphasizing the potential impact of these findings.

Published in the journal, Experimental & Molecular Medicine on July 3, this study received support from the Korea Research Foundation's Cancer Control Research Center by Intercellular Signal Communication -- a program under the Ministry of Science and ICT.

As breast cancer continues to be a significant global health concern affecting millions of lives, studies like these play a crucial role in advancing personalized treatment approaches based on specific genetic mutations. The groundbreaking insights gained from Professor Lee's team provide hope for improved clinical management and better prognostic outcomes for patients diagnosed with triple negative apocrine carcinoma.


Story Source:

Materials provided by Ulsan National Institute of Science and Technology(UNIST). Original written by JooHyeon Heo. Note: Content may be edited for style and length.


Journal Reference:

  1. Ji-Yeon Kim, Sabin Park, Eun Yoon Cho, Jeong Eon Lee, Hae Hyun Jung, Byung Joo Chae, Seok Won Kim, Seok Jin Nam, Soo Youn Cho, Yeon Hee Park, Jin Seok Ahn, Semin Lee, Young-Hyuck Im. Genomic characteristics of triple negative apocrine carcinoma: a comparison to triple negative breast cancer. Experimental & Molecular Medicine, 2023; 55 (7): 1451 DOI: 10.1038/s12276-023-01030-z

Cite This Page:

Ulsan National Institute of Science and Technology(UNIST). "Groundbreaking research unveils genetic characteristics and improved prognosis of triple negative apocrine carcinoma." ScienceDaily. ScienceDaily, 13 September 2023. <www.sciencedaily.com/releases/2023/09/230913122656.htm>.
Ulsan National Institute of Science and Technology(UNIST). (2023, September 13). Groundbreaking research unveils genetic characteristics and improved prognosis of triple negative apocrine carcinoma. ScienceDaily. Retrieved February 22, 2024 from www.sciencedaily.com/releases/2023/09/230913122656.htm
Ulsan National Institute of Science and Technology(UNIST). "Groundbreaking research unveils genetic characteristics and improved prognosis of triple negative apocrine carcinoma." ScienceDaily. www.sciencedaily.com/releases/2023/09/230913122656.htm (accessed February 22, 2024).

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