Featured Research

from universities, journals, and other organizations

New Mechanism For Regulating Gene Expression Discovered

Date:
June 24, 1999
Source:
Northwestern University
Summary:
Tissue differentiation results from a highly regulated process that turns specific genes on and off. Unraveling the complexities of gene regulation and protein expression is crucial to scientists' understanding of developmental birth defects and a variety of other medical conditions. Now, Northwestern researchers have gained new insight into how genes are expressed.

CHICAGO --- From just a single fertilized egg, how does Nature produce the cells, bones and organs that make up a human being?

Related Articles


Tissue differentiation, as it is called, results from a highly regulated process that turns specific genes on and off. Unraveling the complexities of gene regulation and protein expression is crucial to scientists' understanding of developmental birth defects and a variety of other medical conditions.

Now, Northwestern researchers have gained new insight into how genes are expressed.

In the June 23 issue of the journal Nature, cell and molecular biologist Elizabeth Goodwin and colleagues at the Medical School described a new role for TRA-1, one of a family of proteins that regulates gene expression by binding directly to DNA, the carrier of genetic material.

The human members of this protein family have been implicated in a number of diseases, including Creig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, postaxial polydactyly type A, and basal cell carcinoma, the most common form of cancer in humans.

"Understanding how this family functions is central to understanding the roles of these proteins in disease," Goodwin said.

Normally, once a gene is activated and its information is transcribed into messenger RNA (mRNA), the 'copy' moves from the nucleus to the cytoplasm of the cell, where the mRNA is 'translated' into a protein.

The investigators found that, in addition to turning genes on, the TRA-1 protein also can regulate the movement of the mRNA from the nucleus to the cytoplasm.

Their experiments confirmed the new role for TRA-1 protein by showing that it binds to a specific region of the mRNA, thus providing an additional mechanism by which cells can fine-tune the level of protein production during embryo development.

Goodwin is an assistant professor of cell and molecular biology at the Medical School and a researcher in the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

This study was supported by grant number GM 51836-01 from the National Institutes of Health and also by Just Cause, a Chicago-based cancer charity.


Story Source:

The above story is based on materials provided by Northwestern University. Note: Materials may be edited for content and length.


Cite This Page:

Northwestern University. "New Mechanism For Regulating Gene Expression Discovered." ScienceDaily. ScienceDaily, 24 June 1999. <www.sciencedaily.com/releases/1999/06/990624080702.htm>.
Northwestern University. (1999, June 24). New Mechanism For Regulating Gene Expression Discovered. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/1999/06/990624080702.htm
Northwestern University. "New Mechanism For Regulating Gene Expression Discovered." ScienceDaily. www.sciencedaily.com/releases/1999/06/990624080702.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins