Featured Research

from universities, journals, and other organizations

Scientists Identify Gene That Detects DNA Damage

Date:
December 14, 1999
Source:
University Of Wisconsin-Madison
Summary:
Researchers at the UW Medical School have found that mutations in a gene they've been studying for several years can cause ataxia-telangiectasia (A-T). The affected gene appears to play a crucial role in controlling the way cells respond to DNA damage that can lead to cancer.

MADISON, WIS. - Researchers at the UW Medical School have found that mutations in a gene they've been studying for several years can cause ataxia-telangiectasia (A-T). The affected gene appears to play a crucial role in controlling the way cells respond to DNA damage that can lead to cancer.

Related Articles


The report, issued with Malcolm Taylor, a researcher from the United Kingdom, appears in the Dec. 10 issue of Cell.

A-T is a genetic disorder that produces progressive nerve and muscle loss. People with A-T are extremely susceptible to cancer. They can become severely ill if they undergo radiation therapy and some may even be harmed by exposure to low levels of radiation associated with mammography.

On the cellular level, genetic defects related to A-T produce DNA instability and damage. DNA repair mechanisms in A-T patients don't work properly, which can throw cells into serious disarray ending in cancer.

Scientists previously had identified mutations in a single gene, called ATM, as the cause of A-T, but the UW team, led by associate professor of genetics John Petrini, now reports that mutations in a closely linked neighboring gene, called Mre11, can also independently produce A-T.

Petrini's team was the first to identify and describe the Mre11 complex, a protein cluster responsible for detecting DNA damage within cells and thereby alerting them that damage is present.

"We can now definitively say that cooperation between Mre11 and ATM comprises a critical component of the regulatory network that cells activate in response to DNA damage," Petrini said. "Since mutations in this complex affect normal development as well as the ability of cells to respond to DNA damage, we infer that this network is also important for normal growth control and cancer prevention."

The UW team reported last year that mutations in a different member of the Mre11 complex, a gene called Nbs1, causes the genetic disease Nijmegen Breakage Syndrome, which closely resembles A-T.


Story Source:

The above story is based on materials provided by University Of Wisconsin-Madison. Note: Materials may be edited for content and length.


Cite This Page:

University Of Wisconsin-Madison. "Scientists Identify Gene That Detects DNA Damage." ScienceDaily. ScienceDaily, 14 December 1999. <www.sciencedaily.com/releases/1999/12/991214075905.htm>.
University Of Wisconsin-Madison. (1999, December 14). Scientists Identify Gene That Detects DNA Damage. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/1999/12/991214075905.htm
University Of Wisconsin-Madison. "Scientists Identify Gene That Detects DNA Damage." ScienceDaily. www.sciencedaily.com/releases/1999/12/991214075905.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins