Featured Research

from universities, journals, and other organizations

Cattle, Human Genomes Contain Many Identical Genes

Date:
September 13, 2000
Source:
University Of Illinois At Urbana-Champaign
Summary:
The most detailed map ever produced of cattle genes and the first comparison map of cattle and human genomes show that many genes, and even whole chromosomes, are configured in the same way in the two species, scientists report.

CHAMPAIGN, Ill. -- The most detailed map ever produced of cattle genes and the first comparison map of cattle and human genomes show that many genes, and even whole chromosomes, are configured in the same way in the two species, scientists report.

"The comparative map has enormous predictive power," said lead researcher Harris Lewin, director of the W.M. Keck Center for Comparative and Functional Genomics at the University of Illinois.

"For the first time, we can move from a point on the human genome to the equivalent point on the cattle genome. That will allow us to use the map of one species to identify genes controlling important traits in the other, such as those influencing lactation, reproduction and resistance to infectious diseases."

The maps appear in the September issue of the journal Genome Research by scientists at two universities after a three-year collaboration led by Lewin, a professor of animal sciences, holder of the Gutgsell Endowed Chair and director of the UI Biotechnology Center. Among the major contributors to the research were co-authors Mark R. Band, a postdoctoral research associate; Joshua H. Larson, a graduate student in the UI department of animal sciences; and James E. Womack, the W.P. Luse Endowed Professor at Texas A&M University.

A pullout poster of the comparative map is included in the journal, courtesy of AniGenics Inc., an animal genomics company, and Research Genetics, a major supplier of tools and reagents for genome research and subsidiary of Invitrogen Corp.

The research -- funded by the USDA National Research Initiative -- combined the sequencing of small segments of genes, known as expressed sequence tags, and sophisticated bioinformatics tools developed at the UI with a radiation hybrid cell panel, a unique resource for gene mapping developed by Womack’s laboratory.

A total of 1,087 genetic markers were placed on the radiation hybrid map, which includes 768 known genes. About 92 percent of all cattle chromosomal DNA is included on the map. This represents a four-fold increase in the total number of all cattle genes mapped previously, Lewin said.

Among the known genes, 638 (83 percent) could be identified as identical to human genes that also have positional information on human chromosomes, the researchers reported. Knowing the order of the same genes on the chromosomes of humans and cattle permitted the construction of the first "whole-genome comparative map" and revealed large regions of conservation of gene order in the two genomes. An examination of the comparative map revealed up to 149 conserved chromosome segments in humans and cattle, including four whole chromosomes that appear to have the same genes in both species, despite the two species being separated by more than 60 million years of evolution.

Among other firsts in the report were the identification of up to 48 novel genes, predicted mapping of 48 unmapped human genes on the basis of the cattle-map position, and the number of chromosome rearrangements during evolution resulting in the present organization of the cattle and human genomes.

Eventually, Lewin said, the cattle genome will be completely sequenced, ultimately leading to a more detailed picture of the evolutionary events that distinguish the different mammals. "In the end" he said, "we will understand the molecular genetic basis for the major phenotypic differences among the mammals. This will have enormous scientific and practical significance, particularly in the area of food safety, animal health, and the competitiveness of our domestic beef and dairy industries."


Story Source:

The above story is based on materials provided by University Of Illinois At Urbana-Champaign. Note: Materials may be edited for content and length.


Cite This Page:

University Of Illinois At Urbana-Champaign. "Cattle, Human Genomes Contain Many Identical Genes." ScienceDaily. ScienceDaily, 13 September 2000. <www.sciencedaily.com/releases/2000/09/000912070337.htm>.
University Of Illinois At Urbana-Champaign. (2000, September 13). Cattle, Human Genomes Contain Many Identical Genes. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2000/09/000912070337.htm
University Of Illinois At Urbana-Champaign. "Cattle, Human Genomes Contain Many Identical Genes." ScienceDaily. www.sciencedaily.com/releases/2000/09/000912070337.htm (accessed September 1, 2014).

Share This




More Plants & Animals News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Washington Wildlife Center Goes Nuts Over Baby Squirrels

Washington Wildlife Center Goes Nuts Over Baby Squirrels

Reuters - US Online Video (Aug. 30, 2014) An animal rescue in Washington state receives an influx of orphaned squirrels, keeping workers busy as they nurse them back to health. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Newsy (Aug. 29, 2014) In a new study, a promising experimental treatment for Ebola managed to cure a group of infected macaque monkeys. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins