Featured Research

from universities, journals, and other organizations

Increased Uterine Cancer Seen In Mice Injected With Genistein, A Soy Estrogen, As Newborns

Date:
June 7, 2001
Source:
NIH/National Institute Of Environmental Health Sciences
Summary:
Infant mice given genistein developed cancer of the uterus later in life, scientists at the National Institute of Environmental Health Sciences reported today. In the study, published in the June issue of Cancer Research, the scientists treated female mice for five days after birth with genistein, a substance in soy that is similar to the female hormone, estrogen.

Infant mice given genistein developed cancer of the uterus later in life, scientists at the National Institute of Environmental Health Sciences reported today. In the study, published in the June issue of Cancer Research, the scientists treated female mice for five days after birth with genistein, a substance in soy that is similar to the female hormone, estrogen.

Related Articles


"The data suggest that genistein is carcinogenic if exposure occurs during critical periods in a young animal's development," lead author Retha Newbold of NIEHS said.

In the study, newborn mouse pups were injected with an amount of genistein within the range similar to what a newborn human infant might receive in a soy-based infant formula. However, infants receive soy formula by mouth. Christopher Portier, Ph.D., National Toxicology Program associate director said, "These data clearly suggest that more research is needed. NTP, in collaboration with the Food and Drug Administration, is conducting further studies to confirm these findings, to find out whether cancers occur when genistein is given to rodents by mouth, to consider other similar agents, and to examine other possible multigenerational effects." NTP is headquartered at NIEHS in Research Triangle Park, N.C.

NTP said, that because babies are often given soy formula for medical reasons, and because these results need further confirmation and evaluation, parents who have concerns about the use of soy formula should consult their pediatrician.

Kenneth Olden, Ph.D., NIEHS/NTP director, said "This is part of a broad research effort by the NIEHS, the NTP, and our academic research centers to address critical data gaps in identifying the important environmental factors affecting children's health."

Co-authors with Newbold on the genistein study were Wendy Jefferson and Elizabeth Padilla of NIEHS, and Bill C. Bullock of the Wake Forest University School of Medicine, Winston-Salem, N.C. The finding is similar to work Newbold did with diethylstilbestrol (DES) exposure in unborn mice. DES is a powerful synthetic estrogen, while genistein is a much weaker estrogenic agent made by plants. DES was previously given to pregnant mothers to prevent miscarriage and was used as a food additive to fatten chickens and cattle. All uses of DES in the United States have been discontinued because some children of mothers who took the drug during pregnancy developed rare cancers.


Story Source:

The above story is based on materials provided by NIH/National Institute Of Environmental Health Sciences. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute Of Environmental Health Sciences. "Increased Uterine Cancer Seen In Mice Injected With Genistein, A Soy Estrogen, As Newborns." ScienceDaily. ScienceDaily, 7 June 2001. <www.sciencedaily.com/releases/2001/06/010605073109.htm>.
NIH/National Institute Of Environmental Health Sciences. (2001, June 7). Increased Uterine Cancer Seen In Mice Injected With Genistein, A Soy Estrogen, As Newborns. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2001/06/010605073109.htm
NIH/National Institute Of Environmental Health Sciences. "Increased Uterine Cancer Seen In Mice Injected With Genistein, A Soy Estrogen, As Newborns." ScienceDaily. www.sciencedaily.com/releases/2001/06/010605073109.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nanoscale Sensor Could Help Wine Producers and Clinical Scientists

Nanoscale Sensor Could Help Wine Producers and Clinical Scientists

Reuters - Innovations Video Online (Jan. 30, 2015) A nanosensor that mimics the oral effects and sensations of drinking wine has been developed by Danish and Portuguese researchers. Jim Drury saw it in operation. Video provided by Reuters
Powered by NewsLook.com
Dog-Loving Astronaut Wins Best Photo of 2015

Dog-Loving Astronaut Wins Best Photo of 2015

Buzz60 (Jan. 30, 2015) Retired astronaut and television host, Leland Melvin, snuck his dogs into the NASA studio so they could be in his official photo. As Mara Montalbano (@maramontalbano) shows us, the secret is out. Video provided by Buzz60
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Rarest Cat on Planet Caught Attacking Monkeys on Camera

Rarest Cat on Planet Caught Attacking Monkeys on Camera

Buzz60 (Jan. 30, 2015) An African Golden Cat, the rarest large cat on the planet was recently caught on camera by scientists trying to study monkeys. The cat comes out of nowhere to attack those monkeys. Patrick Jones (@Patrick_E_Jones) has the rest. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins