Featured Research

from universities, journals, and other organizations

New Mutant Mouse Repositories Established For Biomedical Research Community

Date:
July 18, 2001
Source:
National Institutes Of Health
Summary:
The National Center for Research Resources (NCRR) at the National Institutes of Health (NIH) announces the official opening of a Mutant Mouse Regional Resource Centers (MMRRCs) network. This network will function as a one-stop shop for the U.S. biomedical research community to donate and acquire mutant mouse models. The MMRRC network is now accepting genetic mouse strains to its collection and invites investigators who have created such models to donate them to the network for broad dissemination upon request by other investigators who will use them in research of human health, disease, and treatments.

Bethesda, Md. — The National Center for Research Resources (NCRR) at the National Institutes of Health (NIH) announces the official opening of a Mutant Mouse Regional Resource Centers (MMRRCs) network. This network will function as a one-stop shop for the U.S. biomedical research community to donate and acquire mutant mouse models. The MMRRC network is now accepting genetic mouse strains to its collection and invites investigators who have created such models to donate them to the network for broad dissemination upon request by other investigators who will use them in research of human health, disease, and treatments. It is estimated that there are more than 3,000 strains of mutant mice that have been created by turning on and off particular genes or by inserting foreign genes into the mouse genome.

Related Articles


"When numerous researchers have access to a shared national resource, such as the MMRRC network," says NCRR Director Dr. Judith Vaitukaitis, "the effectiveness of that resource is maximized relative to its monetary cost and scientific impact." She adds, "Shared resources allow scientists to integrate diverse research expertise, rapidly and effectively study emerging health problems, address complex research queries, and pursue unexpected research opportunities."

The MMRRC network currently includes four repository-distribution facilities located at the University of North Carolina at Chapel Hill; the University of California at Davis; Taconic Farms in New York; and Harlan Sprague Dawley, Inc., in collaboration with the University of Missouri.

The MMRRC network is electronically linked through an NCRR-sponsored MMRRC Informatics Coordinating Center (ICC) to function as one facility. The ICC, which is located at The Jackson Laboratory in Bar Harbor, Maine, provides database and other informatics support to the MMRRCs to give the research community a single entry point to the network through the MMRRC Web site at www.mmrrc.org. This site provides information about submitting candidate strains. By late 2001, the site will also provide detailed phenotypic and genotypic information to researchers interested in searching the network for maintained strains, ordering mice from the facilities, and registering to receive strains being developed.

Generally, each MMRRC facility is equipped to cryopreserve embryos or gametes; rederive strains as needed; and characterize the genetic and phenotypic makeup of the mutants so that models are validated and may optimally serve as models of human disease. Efficient facility systems provide genetic quality control and disease safeguards. The MMRRCs offer expertise in the biology of laboratory mice — covering areas of cryobiology, genetics, comparative pathology, behavioral science, and infectious disease. In addition, each center focuses on specific research areas such as vascular and cancer biology, endocrinology, or neurobiological sciences.

NCRR is this nation's leading Federal sponsor of research resources that enable scientific advances and discoveries in many areas of biomedical research. NCRR-supported research resources provide the scientific research community with access to a diverse array of research technologies, instrumentation, specialized basic and clinical research facilities, animal models (mammalian and nonmammalian), genetic stocks, and biomaterials, including cell lines, tissues, and organs.


Story Source:

The above story is based on materials provided by National Institutes Of Health. Note: Materials may be edited for content and length.


Cite This Page:

National Institutes Of Health. "New Mutant Mouse Repositories Established For Biomedical Research Community." ScienceDaily. ScienceDaily, 18 July 2001. <www.sciencedaily.com/releases/2001/07/010718091336.htm>.
National Institutes Of Health. (2001, July 18). New Mutant Mouse Repositories Established For Biomedical Research Community. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2001/07/010718091336.htm
National Institutes Of Health. "New Mutant Mouse Repositories Established For Biomedical Research Community." ScienceDaily. www.sciencedaily.com/releases/2001/07/010718091336.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Lioness Has Rare Five-Cub Litter

Raw: Lioness Has Rare Five-Cub Litter

AP (Mar. 27, 2015) — A lioness in Pakistan has given birth to five cubs, twice the usual size of a litter. Queen gave birth to two other cubs just nine months ago. (March 27) Video provided by AP
Powered by NewsLook.com
Jockey Motion Tracking Reveals Racing Prowess

Jockey Motion Tracking Reveals Racing Prowess

Reuters - Innovations Video Online (Mar. 26, 2015) — Using motion tracking technology, researchers from the Royal Veterinary College (RVC) are trying to establish an optimum horse riding style to train junior jockeys, as well as enhance safety, health and well-being of both racehorses and jockeys. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Bear Cubs Tumble for the Media

Bear Cubs Tumble for the Media

Reuters - Light News Video Online (Mar. 26, 2015) — Two Andean bear cubs are unveiled at the U.S. National Zoo in Washington, D.C. Alicia Powell reports. Video provided by Reuters
Powered by NewsLook.com
Botswana Talks to End Illegal Wildlife Trade

Botswana Talks to End Illegal Wildlife Trade

AFP (Mar. 25, 2015) — Experts are gathering in Botswana to try to end the illegal wildlife trade that is decimating populations of elephants, rhinos and other threatened species. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins