Featured Research

from universities, journals, and other organizations

Even Moderate Caloric Restriction Lowers Cancer Risk In Mice

Date:
April 25, 2002
Source:
Federation Of American Societies For Experimental Biology
Summary:
A new National Cancer Institute study reported April 23 by Dr. Volker Mai at the Experimental Biology 2002 meeting in New Orleans shows that even moderate caloric restriction reduced by 60 percent the number of precancerous intestinal polyps in mice at high risk of gastrointestinal cancers (mice with the same genetic mutation seen in some humans who develop these cancers). Don’t think you can eat less? Then eat better. Animals eating as much as they wanted of a diet high in olive oil, fruits and vegetables also had a third fewer polyps than control mice.

A new National Cancer Institute study reported April 23 by Dr. Volker Mai at the Experimental Biology 2002 meeting in New Orleans shows that even moderate caloric restriction reduced by 60 percent the number of precancerous intestinal polyps in mice at high risk of gastrointestinal cancers (mice with the same genetic mutation seen in some humans who develop these cancers). Don’t think you can eat less? Then eat better. Animals eating as much as they wanted of a diet high in olive oil, fruits and vegetables also had a third fewer polyps than control mice.

Related Articles


That’s good news, says Dr. Mai, since this moderate caloric restriction and/or the use of a diet in which fat came from olive oil are more likely to be followed by humans and have been shown to have broad health benefits even beyond an effect on gastrointestinal cancer risk. The findings are more troubling, he adds, when you think about the continuing trend of high caloric food intake observed in most developed nations. How much is too much? Working with a well-proven mouse model of intestinal cancer, the NCI researchers allowed some mice to eat as much food as they wanted. As mice will, they ate almost all the time, with weight gain to show for it. The researchers measured the mice’s food intake and limited similar mice to only 60 percent of the amount. This satisfied all their nutritional requirements and provided a goodly amount of food to eat as well. The result: the number of the precancerous polyps also went down by 60 percent compared to the mice eating as much as they wanted.

Previous mouse studies, like epidemiological studies of humans, have shown that what gets eaten also has an effect on colorectal cancers. So Dr. Mai and his colleagues at NCI compared the number of polyps in mice on a high fat diet, mice on a “healthy” diet with olive oil and fruit and vegetable extract, and mice on the standard laboratory mouse diet. Mice consuming a diet high on fruits and vegetables had 33 percent fewer polyps than the control mice, whereas the mice on the high fat diet had slightly elevated polyp numbers.

The researchers also looked at exercise. A moderate amount of exercise did lower the number of polyps but the difference was not statistically significant. Dr. Mai is a Cancer Prevention Fellow in the Nutritional Epidemiology Branch of the NCI. He says the research team, headed by Dr. Steve Hursting, is planning to look at different combinations of caloric intake, fat, and exercise in an effort to determine effective intervention combinations that have the potential to be tested in humans.


Story Source:

The above story is based on materials provided by Federation Of American Societies For Experimental Biology. Note: Materials may be edited for content and length.


Cite This Page:

Federation Of American Societies For Experimental Biology. "Even Moderate Caloric Restriction Lowers Cancer Risk In Mice." ScienceDaily. ScienceDaily, 25 April 2002. <www.sciencedaily.com/releases/2002/04/020424073022.htm>.
Federation Of American Societies For Experimental Biology. (2002, April 25). Even Moderate Caloric Restriction Lowers Cancer Risk In Mice. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2002/04/020424073022.htm
Federation Of American Societies For Experimental Biology. "Even Moderate Caloric Restriction Lowers Cancer Risk In Mice." ScienceDaily. www.sciencedaily.com/releases/2002/04/020424073022.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Reuters - Light News Video Online (Dec. 19, 2014) Millions of monarch butterflies begin to descend onto Mexico as part of their annual migration south. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins