Featured Research

from universities, journals, and other organizations

Fat That May Benefit Diabetics Reduces Weight, Blood Sugar

Date:
January 29, 2003
Source:
Ohio State University
Summary:
Supplementing the diet with a certain fatty acid may lead to better weight control and disease management in diabetics, a new study suggests. Dabetics who added an essential fatty acid called conjugated linoleic acid (CLA) to their diets had lower body mass as well as lower blood sugar levels by the end of the eight-week study.

COLUMBUS, Ohio – Supplementing the diet with a certain fatty acid may lead to better weight control and disease management in diabetics, a new study suggests.

Diabetics who added an essential fatty acid called conjugated linoleic acid (CLA) to their diets had lower body mass as well as lower blood sugar levels by the end of the eight-week study. Hyperglycemia, or high blood sugar, is a hallmark of diabetes.

Researchers also found that higher levels of this fatty acid in the bloodstream meant lower levels of leptin, a hormone thought to regulate fat levels. Scientists think that high leptin levels may play a role in obesity, one of the biggest risk factors for adult-onset diabetes.

"In previous work, we found that CLA delayed the onset of diabetes in rats," said Martha Belury, the senior author of the study and an associate professor of human nutrition at Ohio State University. "In this study, we found that it also helped improve the management of adult-onset diabetes in humans."

CLA is made up of various fatty acid isomers – compounds that share the same chemical formula but differ in chemical structure. Related isomers can have very different effects.

In the current study, the researchers found that one particular CLA isomer, t10c12-CLA, helped control both body weight and leptin levels. Nutritionists sometimes call this isomer the 10-12, isomer.

The research appears in the January issue of the Journal of Nutrition. Belury conducted the study while with the department of foods and nutrition at Purdue University. She is continuing the research at Ohio State.

The researchers asked 21 people with adult-onset diabetes to take either a supplement containing a mix of rumenic acid and 10-12 isomer or a safflower oil supplement as a control. The group was divided roughly in half. Rumenic acid is the predominant isomer in foods that contain CLA, while the 10-12 isomer is less abundant.

Participants were instructed to take their respective supplements every day for eight weeks.

"The amount of CLA, how long it's taken and the type taken all impact the fatty acid's ability to affect obesity in humans, and therefore help manage diabetes."

While CLA supplements are available to consumers, Belury encourages diabetics to get their CLA from food sources – primarily beef, lamb and dairy products.

"Not only does it taste better, it's also safer and more beneficial to get the nutrients from food," she said. "Besides, we don't yet know the long-term effects of taking CLA in supplement form."

At the end of the trial, the researchers took blood samples from each participant to check CLA levels. By then, fasting blood glucose levels had decreased in nine of the 11 people taking the CLA supplement, but only in two of the 10 taking safflower supplements, meaning that CLA was helping to control certain symptoms of diabetes.

Fasting blood glucose levels decreased nearly five-fold in patients taking CLA, compared to patients taking the safflower oil.

The researchers also studied the impact each isomer had on changes in body weight and levels of the hormone leptin.

It was the 10-12 isomer, and not rumenic acid, that was linked to a reduction in body weight and leptin levels. While the average weight loss among patients taking CLA supplements was small (about 3.5 pounds), they had been asked to not change their normal caloric intake during the study. The group taking safflower supplements neither lost nor gained weight. Leptin levels decreased in the CLA group, and rose slightly in the safflower group.

"The effect of the 10-12 isomer on reducing body mass and leptin levels was key," Belury said, adding that other researchers have shown the 10-12 isomer to be helpful in reducing body mass in animals.

"The amount of CLA, how long it's taken and the type taken all impact the fatty acid's ability to affect obesity in humans, and therefore help manage diabetes," Belury said.

A 2002 study conducted by the Diabetes Prevention Program Research Group found that a modest reduction in body weight resulted in a 58 percent reduction in the incidence of diabetes in a group of people at high risk for developing the disease.

Belury conducted the study with Annie Mahon of the department of foods and nutrition at Purdue University and Sebastiano Banni of the department of experimental biology at the University of Cagliari, Italy.

The research received support from Pharmanutrients, Inc., Lake Bluff, Ill., and Natural, Inc., Chicago. Although Belury has consulted for both companies in the past, she was not a paid consultant during the time of this study.


Story Source:

The above story is based on materials provided by Ohio State University. Note: Materials may be edited for content and length.


Cite This Page:

Ohio State University. "Fat That May Benefit Diabetics Reduces Weight, Blood Sugar." ScienceDaily. ScienceDaily, 29 January 2003. <www.sciencedaily.com/releases/2003/01/030129080354.htm>.
Ohio State University. (2003, January 29). Fat That May Benefit Diabetics Reduces Weight, Blood Sugar. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2003/01/030129080354.htm
Ohio State University. "Fat That May Benefit Diabetics Reduces Weight, Blood Sugar." ScienceDaily. www.sciencedaily.com/releases/2003/01/030129080354.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins