Featured Research

from universities, journals, and other organizations

Nanotech Decoys For Viruses

Date:
March 20, 2003
Source:
University Of California, Davis
Summary:
Using nanotechnology to stop HIV viruses from entering cells is the ultimate aim of a new project at the University of California, Davis. The researchers hope to create tiny particles that can interfere with the proteins that viruses such as HIV use to attach to cells.

Using nanotechnology to stop HIV viruses from entering cells is the ultimate aim of a new project at the University of California, Davis. The researchers hope to create tiny particles that can interfere with the proteins that viruses such as HIV use to attach to cells.

"The idea is to make decoys for the virus," said Jacquelyn Gervay Hague, professor of chemistry at UC Davis and principal investigator on the grant.

HIV attaches itself to a host cell through a protein called gp120 on the virus surface. Gp120 sticks to the CD4 protein on human white blood cells and also to a fatty molecule called galactosyl ceramide, or GalCer. GalCer is found in the membranes of many different types of cell, including cells lining the gut and vagina. Researchers think that binding of gp120 to GalCer may be important in sexual transmission of HIV.

GalCer can form patterns in the cell membrane that allow many gp120 proteins to bind in a specific manner, Gervay Hague said. Materials scientist Marjorie Longo and her lab are studying how GalCer forms these patterns in artificial membranes and how they affect binding to viruses.

If the researchers find a pattern that maximizes binding, they will use tools developed by chemist Gang-yu Liu to recreate those patterns on lipid-coated "quantum dots," tiny particles a few tens of atoms in size. The quantum dots are made by Susan Kauzlarich, a professor of chemistry who studies these very small particles. The particles will be tested for antiviral activity by Satya Dandekar, professor and chair of microbiology and immunology at the UC Davis School of Medicine.

The researchers' ultimate goal is to create a quantum dot that can stick to the virus and prevent it from entering human cells.

The group has already made gold nanoparticles coated with a non-patterned membrane. These particles are not toxic to cells and were able to bind gp120, Gervay Hague said.

The work is funded by a $1.2 million Nanoscale Interdisciplinary Research Team grant from the National Science Foundation.


Story Source:

The above story is based on materials provided by University Of California, Davis. Note: Materials may be edited for content and length.


Cite This Page:

University Of California, Davis. "Nanotech Decoys For Viruses." ScienceDaily. ScienceDaily, 20 March 2003. <www.sciencedaily.com/releases/2003/03/030320074955.htm>.
University Of California, Davis. (2003, March 20). Nanotech Decoys For Viruses. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2003/03/030320074955.htm
University Of California, Davis. "Nanotech Decoys For Viruses." ScienceDaily. www.sciencedaily.com/releases/2003/03/030320074955.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com
House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Uganda on Alert for Ebola but No Confirmed Cases

Uganda on Alert for Ebola but No Confirmed Cases

AFP (July 31, 2014) Uganda's health minister said on Thursday that there are no confirmed cases of Ebola in the country, but that it remained on alert for cases of the deadly virus. Uganda has suffered Ebola outbreaks in the past, most recently in 2012. Duration: 00:59 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins