Featured Research

from universities, journals, and other organizations

Using 'Sick Cells,' Blood Tests May One Day ID Heart Attack, Stroke

Date:
July 21, 2003
Source:
American Association For Clinical Chemistry
Summary:
A clinician can determine your lifestyle, take some key physiological readings, and make an educated prediction that an individual might have a heart attack or stroke. But what if there was an actual laboratory test that could identify biological markers that could indicate the onset of either attack, and yet allow emergency medical intervention that would save a life or full mental capacity.

(Philadelphia, PA) -- Each year, there are 1.3 million admissions to U.S. hospitals for angina, ischemia of the heart muscle usually caused by coronary disease, or myocardial infarction, a heart attack. Heart failure will be the cause of 40 percent of deaths in America this year – most are unexpected, and cannot be predicted by the medical community.

Another unexpected event to the human body is the stroke, an acute impairment of cerebral circulation that lasts more than 24 hours, resulting in irreversible brain damage. Strokes are also a leading killer; some 750,000 Americans this year will have a stroke; 160,000 of them will die.

A clinician can determine your lifestyle, take some key physiological readings, and make an educated prediction that an individual might have a heart attack or stroke. But what if there was an actual laboratory test that could identify biological markers that could indicate the onset of either attack, and yet allow emergency medical intervention that would save a life or full mental capacity.

Such a test for a heart attack or stroke may be only a few short years away, according to a researcher participating in the development of this potentially invaluable diagnostic tool. Robert H. Christenson, PhD, Professor of Pathology, University of Maryland Medical School, Baltimore, MD, will present an assessment of where the tests development stands in a presentation, "Nourin: An Early Specific Marker of Cardiac Ischemia?" at the 55th Annual Meeting of the American Association of Clinical Chemistry (AACC) being held July 20-24, 2003, at the Pennsylvania Convention Center, Philadelphia, PA. More than 16,000 attendees are expected.

What Are Nourins?

Many dictionaries and medical reference books will not carry this term because it was formerly known as a "cardiac-derived neutrophil chemotactic factor," a factor that is released by heart tissues in response to reversible and irreversible ischemia (inadequate circulation of blood to the myocardium, usually as a result of coronary artery disease).

What makes this marker important is that ischemia does not kill cells right away. There is a cardiac-derived isoform specific for ischemia, and when the condition occurs, the marker or chemotactic factor is released, drawing neutrophils into the tissue for repair of injured tissue. Nourin-1 is the earliest biological signal that this form of heart failure is occurring. Accordingly, Dr. Christensen believes that if Nourins can be identified, medicines can be administered to the ischemic patient, saving cells and the patient's life.

He suggests that a blood test is the optimum test to identify Nourins, a 3,000 molecular-weight protein. Presently, studies are underway to develop a better antibody, which could indicate when the cells are sick. He adds that such a test is three to five years away from use in our nation's laboratories.

Stringing the Stroke Markers

Strokes are related to heart disease and therefore have the potential for early intervention due to marker identification. There is presently no diagnostic test to predict the onset of a stroke. But Dr. Christenson and others believe that a blood test could identify a panel of markers, stringing together a series of proteins that could lead to the development of strategies for preventing strokes.

Such an effort is already in trials with Biositeฎ Inc., San Diego, CA. The company has already developed the Triage BNP test, currently the only blood test now in use at hospitals for measuring b-type natriuretic peptides and their relation to cardiac disease.

Both tests will have a profound impact on efforts to treat heart disease and cerebral circulation disorders. This presentation before the managers of our nation's leading laboratories is an important first step in this diagnostic revolution.

The American Association for Clinical Chemistry (AACC) is the world's most prestigious professional association for clinical laboratorians, clinical and molecular pathologists, and others in related fields. AACC's members are specialists trained in the areas of laboratory testing, including genetic disorders, infectious diseases, tumor markers and DNA. Their primary professional commitment is utilizing tests to detect, treat and monitor disease.


Story Source:

The above story is based on materials provided by American Association For Clinical Chemistry. Note: Materials may be edited for content and length.


Cite This Page:

American Association For Clinical Chemistry. "Using 'Sick Cells,' Blood Tests May One Day ID Heart Attack, Stroke." ScienceDaily. ScienceDaily, 21 July 2003. <www.sciencedaily.com/releases/2003/07/030721085034.htm>.
American Association For Clinical Chemistry. (2003, July 21). Using 'Sick Cells,' Blood Tests May One Day ID Heart Attack, Stroke. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2003/07/030721085034.htm
American Association For Clinical Chemistry. "Using 'Sick Cells,' Blood Tests May One Day ID Heart Attack, Stroke." ScienceDaily. www.sciencedaily.com/releases/2003/07/030721085034.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins