Featured Research

from universities, journals, and other organizations

Parasite Lipids May Help Treat Asthma Or Diabetes

Date:
November 12, 2003
Source:
Netherlands Organization For Scientific Research
Summary:
Dutch research has demonstrated that lipids from the parasite schistosoma can inhibit human immune responses. This property makes the lipids interesting for a possible new treatment of diseases such as asthma and diabetes where the immune system responds inappropriately.

Dutch research has demonstrated that lipids from the parasite schistosoma can inhibit human immune responses. This property makes the lipids interesting for a possible new treatment of diseases such as asthma and diabetes where the immune system responds inappropriately.

Related Articles


During her doctoral research, Desiree van der Kleij discovered that lipids from the parasite schistosoma steer the development of the immune system in a certain direction. Cells from the innate immune system, so-called dendritic cells, respond to these lipids. During this response these cells can initiate the development of so-called regulatory T-cells. These regulatory T-cells subsequently suppress the activity of other cells in the immune system.

The researcher discovered that one of the lipids with this steering effect on dendritic cells contains a fatty acid that does not occur in humans. She also demonstrated that this specific lipid of the parasite activates a specific receptor on dendritic cells. Once the receptor had been blocked, it was found that regulatory T-cells no longer developed after dendritic cells had been stimulated with the parasite lipid.

Diseases such as diabetes and asthma are caused by inappropriate immune responses to certain substances. Molecules which can inhibit the immune responses, such as the lipids of schistosomes, could be used to suppress these errant responses. The use of lipids from schistosomes for this purpose will be investigated in a follow-up study funded by the Netherlands Organisation for Scientific Research.

In the immune system, dendritic cells detect the presence of pathogens in the body. These cells then direct the development of immune responses so that a type of immune response develops which is appropriate to combat the pathogen present. The pathogen could be a bacteria, but equally a virus or a parasite.

Schistosomes are parasitic worms. More than 200 million people worldwide are infected with the worm. The majority of these people live in Africa and South America. The worms can survive in their host for years. Although infected persons develop an immune response during an infection, the parasite significantly suppresses the activity of the immune system in people who are chronically infected with these worms. This suppression is probably caused by regulatory T-cells.

###

The research was funded by the Netherlands Organisation for Scientific Research.


Story Source:

The above story is based on materials provided by Netherlands Organization For Scientific Research. Note: Materials may be edited for content and length.


Cite This Page:

Netherlands Organization For Scientific Research. "Parasite Lipids May Help Treat Asthma Or Diabetes." ScienceDaily. ScienceDaily, 12 November 2003. <www.sciencedaily.com/releases/2003/11/031112074434.htm>.
Netherlands Organization For Scientific Research. (2003, November 12). Parasite Lipids May Help Treat Asthma Or Diabetes. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2003/11/031112074434.htm
Netherlands Organization For Scientific Research. "Parasite Lipids May Help Treat Asthma Or Diabetes." ScienceDaily. www.sciencedaily.com/releases/2003/11/031112074434.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Boy or Girl? Intersex Awareness Is on the Rise

Boy or Girl? Intersex Awareness Is on the Rise

AP (Apr. 17, 2015) At least 1 in 5,000 U.S. babies are born each year with intersex conditions _ ambiguous genitals because of genetic glitches or hormone problems. Secrecy and surgery are common. But some doctors and activists are trying to change things. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins