Featured Research

from universities, journals, and other organizations

Keeping Drugs Stable Without Refrigeration

Date:
June 21, 2004
Source:
National Institute Of Standards And Technology
Summary:
A spoonful of sugar may help the medicine go down, but it may take only a thin coating of freeze-dried sugar to keep insulin, vaccines and other heat-sensitive, protein-based drugs working reliably even when stored at room temperature and above.

A spoonful of sugar may help the medicine go down, but it may take only a thin coating of freeze-dried sugar to keep insulin, vaccines and other heat-sensitive, protein-based drugs working reliably even when stored at room temperature and above. Widespread availability of stable, room-temperature therapeutic proteins and vaccines would lower the cost and increase the convenience of these drugs, and could dramatically improve distribution in areas of developing nations where refrigeration may be limited.

New measurements taken by National Institute of Standards and Technology (NIST) scientists and published in the June edition of Biophysical Journal show that rapidly solidified sugars preserve such proteins best when they suppress tiny, molecular motions lasting a nanosecond or less. NIST scientists Christopher Soles and Marcus Cicerone used instruments at the NIST Center for Neutron Research to help them view nanoscale molecular motions of sugar mixtures that were designed to encase proteins. They found a striking correlation between sugar mixtures that provide unusually good protein stabilization and a suppression of very fast motions in the sugars.

Scientists have known for more than a decade that “glassy” sugars can preserve medicines by encasing the proteins in a protective coating. The NIST measurements show that tiny molecular “wiggling” that facilitates protein degradation occurs at time and length scales smaller than once thought to matter. They found that diluting sugars that become “glassy” at a relatively high temperature with the right amount of glycerol formed a stiffer material, further restricting the protein’s movement. It's as though the sugar glove is now made of cement instead of cloth, says Cicerone.


Story Source:

The above story is based on materials provided by National Institute Of Standards And Technology. Note: Materials may be edited for content and length.


Cite This Page:

National Institute Of Standards And Technology. "Keeping Drugs Stable Without Refrigeration." ScienceDaily. ScienceDaily, 21 June 2004. <www.sciencedaily.com/releases/2004/06/040621075225.htm>.
National Institute Of Standards And Technology. (2004, June 21). Keeping Drugs Stable Without Refrigeration. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2004/06/040621075225.htm
National Institute Of Standards And Technology. "Keeping Drugs Stable Without Refrigeration." ScienceDaily. www.sciencedaily.com/releases/2004/06/040621075225.htm (accessed August 22, 2014).

Share This




More Matter & Energy News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Flower Power! Dandelions Make Car Tires?

Flower Power! Dandelions Make Car Tires?

Reuters - Business Video Online (Aug. 20, 2014) Forget rolling on rubber, could car drivers soon be traveling on tires made from dandelions? Teams of scientists are racing to breed a type of the yellow flower whose taproot has a milky fluid with tire-grade rubber particles in it. As Joanna Partridge reports, global tire makers are investing millions in research into a new tire source. Video provided by Reuters
Powered by NewsLook.com
Awesome New Camouflage Sheet Was Inspired By Octopus Skin

Awesome New Camouflage Sheet Was Inspired By Octopus Skin

Newsy (Aug. 19, 2014) Scientists have developed a new device that mimics the way octopuses blend in with their surroundings to hide from dangerous predators. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
Green Power Blooms as Japan Unveils 'hydrangea Solar Cell'

Green Power Blooms as Japan Unveils 'hydrangea Solar Cell'

AFP (Aug. 19, 2014) A solar cell that resembles a flower is offering a new take on green energy in Japan, where one scientist is searching for renewables that look good. Duration: 01:29 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins