Featured Research

from universities, journals, and other organizations

More Than 200 New Genes In Acute Myocardial Infarction Discovered

Date:
August 17, 2004
Source:
Tekes (National Technology Agency Of Finland)
Summary:
More than 200 new genes in Acute Myocardial Infarction discovered Finnish company Jurilab has announced the completion of a genome-wide scan in Acute Myocardial Infarction in the East Finland Founder Population.

More than 200 new genes in Acute Myocardial Infarction discovered Finnish company Jurilab has announced the completion of a genome-wide scan in Acute Myocardial Infarction in the East Finland Founder Population.

The DNA samples used in the study were collected in the 1980’s from a genetically-homogeneous population that can be accurately traced back to a few hundred founders in the 1600’s. In the study, coronary events recorded prospectively during almost 20 years in families with several members having coronary disease, were compared with extremely healthy controls.

The prospective study design is invaluable in that it eliminates a bias, which is commonly present in conventional case-control studies. The Jurilab gene discovery team typed over 100,000 single-nucleotide-polymorphisms covering the majority of structural blocks in the genome of Eastern Finns, who share exceptionally large genomic regions. Jurilab’s proprietary data-mining software was used in the statistical analysis.

The study was supported by Tekes (National Technology Agency of Finland) and carried out in collaboration with the University of Kuopio. Jurilab participated in Tekes’ Diagnostics 2000 Technology Programme. Technology programme focused on clinical diagnostics and its budget was EUR 33 million.

Jurilab΄s study confirms companys previous assumptions concerning the total number of disease-related genes involved in coronary disease, and gives invaluable insight into the interplay of different genes and pathways leading to coronary disease. The study has re-affirmed the majority of genes previously known to be associated with AMI. The new genes discovered include also ones, which appear to give humans a strong protection against coronary disease.

"These discoveries open up a new chapter in the development of predictive tests and much improved therapeutics for coronary heart disease", said Professor Jukka T. Salonen, Jurilab’s chief scientific officer, and "The successful AMI GWS constitutes a proof-of-concept for Jurilab’s fast and inexpensive gene discovery approach. We are in the process of carrying out similar studies in our main focus areas of cardiovascular and metabolic diseases".


Story Source:

The above story is based on materials provided by Tekes (National Technology Agency Of Finland). Note: Materials may be edited for content and length.


Cite This Page:

Tekes (National Technology Agency Of Finland). "More Than 200 New Genes In Acute Myocardial Infarction Discovered." ScienceDaily. ScienceDaily, 17 August 2004. <www.sciencedaily.com/releases/2004/08/040815233542.htm>.
Tekes (National Technology Agency Of Finland). (2004, August 17). More Than 200 New Genes In Acute Myocardial Infarction Discovered. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2004/08/040815233542.htm
Tekes (National Technology Agency Of Finland). "More Than 200 New Genes In Acute Myocardial Infarction Discovered." ScienceDaily. www.sciencedaily.com/releases/2004/08/040815233542.htm (accessed April 21, 2014).

Share This



More Health & Medicine News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Foods Are Getting Pricier

Breakfast Foods Are Getting Pricier

AP (Apr. 21, 2014) — Breakfast is now being served with a side of sticker shock. The cost of morning staples like bacon, coffee and orange juice is on the rise because of global supply problems. (April 21) Video provided by AP
Powered by NewsLook.com
Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) — Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins