Featured Research

from universities, journals, and other organizations

AIDS And Tomatoes

Date:
August 18, 2004
Source:
Informnauka (Informscience) Agency
Summary:
Scientists from Novosibirsk are currently creating a pleasant and harmless vaccine - an edible one. So far, they managed to incorporate the protein gene - HIV antigen in tomatoes. The research is supported by International Science and Technology Center (ISTC).

Scientists from Novosibirsk are currently creating a pleasant and harmless vaccine - an edible one. So far, they managed to incorporate the protein gene - HIV antigen in tomatoes. The research is supported by International Science and Technology Center (ISTC).

All patients would be overjoyed to get edible vaccines, contained in vegetables and fruit. Imagine, a patient eats a vaccine and this way gets protected from a dangerous infection. However, this is not a fantasy, the fact being confirmed by the research carried out by scientists all over the world. They are working hard to create an edible vaccine against HIV - a lethal virus. Russian researchers from 'Vector' State Scientific Center for Virology and Biotechnology jointly with the specialists from the Institute for Biological Chemistry and Fundamental Medicine in Novosibirsk, Siberian Institute for Plants Physiology and Biochemistry, Irkutsk, and the scientists from the Department for Agricultural Research, Maryland, USA are also working at this challenge. They are not at the stage of creating the vaccine yet, but the biologists have managed to incorporate the right gene into tomato plants and have proved that the protein required for the vaccine is not only contained in tomato leaves, but in tomato fruit. And this is a considerable achievement.

By the way, tomatoes have not been chosen by chance. The matter is that transgenic plants, which contain protein- HIV antigen, have already been cultivated, but these plants are either not edible, like tobacco, or must be thermally processed, like potatoes, and this way they practically lose their healing powers. To this end tomato serves ideally. The good thing is that this vegetable grows pretty well in Russia, compared to bananas, already used by Western scientists to produce vaccines.

In order to introduce the right gene into tomatoes, the scientists have constructed the so-called agro-bacterial vector. In the agro bacteria culture the researchers have collected the hybrid plasmid (circular DNA), where they have inserted the artificial protein gene, comprising key sites of two HIP virus proteins. This protein should serve as an antigen in order to get the immune response, and the important point is, not just for one virus protein, but for several ones. It was also required to add the cauliflower mosaic virus gene to the combination, and it was used as a promoter, which controls the functioning of the targeted gene. This complex construction together with the bacteria culture was introduced into tomato germs with the help of an injection needle. Afterwards, the germs were cultivated on a special nutrient medium, and those plants which grew roots, were planted into the soil and cultivated in the hothouse till they matured and developed fruit. With the help of the polymerase chain reaction the researchers have proved that the gene is present in the plants, and with the help of other methods have tested that it works - the protein is present in the leaves and, even more important, in tomato plant fruit.

However, the scientists have gone further - they needed to test if the gene could be passed over to the next generations of plants. They took the seeds of the transgenic tomatoes, couched them and grew the second generation tomatoes, which also happened to be transgenic. The ante-gene protein was present in their fruit.

"The cultivated transgenic tomato plants are worth to be considered in terms of creating an edible vaccine against HIV/AIDS and hepatite B on their basis", this conclusion was made by the scientists. But how is this prospective edible vaccine supposed to work? Protein-antigen would interact with the mucous membrane of the gastrointestinal tract, activating the so-called mucous type of immune protection. As a result, the organism would synthesize antibodies against virus protein. The advantage of edible vaccines compared to injections is the absence of risk of passing over infections, edible vaccines are comparatively inexpensive and do not require any special facilities for storage and transportation. And finally, they are tasty!


Story Source:

The above story is based on materials provided by Informnauka (Informscience) Agency. Note: Materials may be edited for content and length.


Cite This Page:

Informnauka (Informscience) Agency. "AIDS And Tomatoes." ScienceDaily. ScienceDaily, 18 August 2004. <www.sciencedaily.com/releases/2004/08/040816001548.htm>.
Informnauka (Informscience) Agency. (2004, August 18). AIDS And Tomatoes. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2004/08/040816001548.htm
Informnauka (Informscience) Agency. "AIDS And Tomatoes." ScienceDaily. www.sciencedaily.com/releases/2004/08/040816001548.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins