Featured Research

from universities, journals, and other organizations

Wound Healers Cause Skin Disease

Date:
October 15, 2004
Source:
Netherlands Organization For Scientific Research
Summary:
Dutch researcher Manon Franssen has shown that cells which heal the skin following an injury play an important role in the development of the skin disease psoriasis. In people with psoriasis, the skin peels much faster than normal so that it flakes and becomes inflamed.

Dutch researcher Manon Franssen has shown that cells which heal the skin following an injury play an important role in the development of the skin disease psoriasis. In people with psoriasis, the skin peels much faster than normal so that it flakes and becomes inflamed.

Franssen investigated the transit amplifying cells in the uppermost layer of the skin. These cells develop from stem cells (general unspecialised cells) and specialise into skin cells when new skin cells are needed. The transit amplifying cells are involved in the healing of the skin following an injury and in the regular renewing of the skin.

Normally these cells wait until they receive a signal to develop into skin cells. Franssen discovered that in people with psoriasis, some of the transit amplifying cells divide without waiting for a signal. As a result of this, too many skin cells develop and the skin is renewed more quickly than normal. However, when Franssen cultured the transit amplifying cells from the skin of psoriasis patients, these cells grew less quickly. Exactly how the cell division of transit amplifying cells and stem cells is regulated, is not yet clear.

In the case of psoriasis, not only is there a more rapid renewal of the skin, but the number of cell layers on the surface also increases. The skin condition causes red marks that are rich in blood and often inflamed. These red marks are covered with shiny white flakes of skin and sometimes itch. Psoriasis is not infectious.

A cure for the disease is still not available and at present only the symptoms can be controlled. According to the Dutch Psoriasis Society about 300,000 people in the Netherlands suffer from a form of this disease. Stem cell therapy might be able to provide a cure for them in the future.

Stem cells currently form an important research area in medicine. Stem cell therapy – the replacement of defective or absent stem cells, tissues or organs in patients – should be able to cure many diseases in the future.

Stem cells from the uppermost layer of the skin have never been isolated. The isolation of their descendants, the transit amplifying cells, is an important step in the right direction. By culturing these cells from patients, complete pieces of skin can be reproduced. These are extremely useful in the treatment of burns, bedsores or skin cancer. The culturing of 'diseased' skin offers the possibility of thoroughly studying diseases and testing new treatments.

The research was funded by the Netherlands Organisation for Scientific Research.


Story Source:

The above story is based on materials provided by Netherlands Organization For Scientific Research. Note: Materials may be edited for content and length.


Cite This Page:

Netherlands Organization For Scientific Research. "Wound Healers Cause Skin Disease." ScienceDaily. ScienceDaily, 15 October 2004. <www.sciencedaily.com/releases/2004/10/041012084302.htm>.
Netherlands Organization For Scientific Research. (2004, October 15). Wound Healers Cause Skin Disease. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2004/10/041012084302.htm
Netherlands Organization For Scientific Research. "Wound Healers Cause Skin Disease." ScienceDaily. www.sciencedaily.com/releases/2004/10/041012084302.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins