Featured Research

from universities, journals, and other organizations

'Rosetta' Software To Unlock Secrets Of Many Human Proteins

Date:
January 22, 2005
Source:
University Of Washington
Summary:
University of Washington TechTransfer recently licensed software that will give scientists a huge advantage in the fight against disease. The software, known as Rosetta, predicts how proteins fold, information that is highly valuable to biological and biomedical researchers.

University of Washington TechTransfer recently licensed software that will give scientists a huge advantage in the fight against disease.

The software, known as Rosetta, predicts how proteins fold, information that is highly valuable to biological and biomedical researchers.

UW Tech Transfer's Digital Ventures licensed Rosetta software without charge to the Institute for Systems Biology (ISB), a non-profit research organization. The institute has partnered with IBM and United Devices, an Austin-based company, to create the Human Proteome Folding Project, a global effort to determine the structures of the approximately 60 percent of human proteins with no known function.

"How proteins fold determines how they are structured," said Lars Malmstroem of the UW laboratory that developed the program, "And how they are structured is related to their function in the body."

Because there is an astronomical number of possible conformations for a given protein, collecting the data would take many thousands of lifetimes to complete with conventional computers, said Dr. Richard Bonneau, one of the researchers.

But by summoning the computing power of millions of volunteers around the world, he said, the task will be completed in less than a year.

IBM's World Community Grid, which was built using grid technology developed by United Devices, will enable millions of people to volunteer their personal computers to run Rosetta during periods of computer downtime.

The information will be entered into a publicly accessible database, which scientists can then use to conduct research into new drugs and treatments.

Rosetta works by virtually folding protein sequences into thousands of possible shapes, based on certain protein folding "rules" known by scientists. These rules are summarized in the program and are termed the "Rosetta score." The program tries a great many conformations and returns those with the lowest Rosetta scores; these conformations come closest to the actual shape of the protein.

Rosetta was developed in the laboratory of UW Professor David Baker by a large team of scientists and students. Former post-doctoral fellow Richard Bonneau, who is now with the ISB, is the technical lead for the project. Rosetta software is available for licensing at: http://depts.washington.edu/ventures/UW_Technology/Licensing/.


Story Source:

The above story is based on materials provided by University Of Washington. Note: Materials may be edited for content and length.


Cite This Page:

University Of Washington. "'Rosetta' Software To Unlock Secrets Of Many Human Proteins." ScienceDaily. ScienceDaily, 22 January 2005. <www.sciencedaily.com/releases/2005/01/050121101919.htm>.
University Of Washington. (2005, January 22). 'Rosetta' Software To Unlock Secrets Of Many Human Proteins. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2005/01/050121101919.htm
University Of Washington. "'Rosetta' Software To Unlock Secrets Of Many Human Proteins." ScienceDaily. www.sciencedaily.com/releases/2005/01/050121101919.htm (accessed August 22, 2014).

Share This




More Computers & Math News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Families Can Now Ask Twitter To Remove Photos Of Deceased

Families Can Now Ask Twitter To Remove Photos Of Deceased

Newsy (Aug. 20, 2014) In the wake of a high-profile harassment case, Twitter says family members can ask for photos of dying or dead relatives to be taken down. Video provided by Newsy
Powered by NewsLook.com
Ballmer Leaves Microsoft's Board, Has Advice For Nadella

Ballmer Leaves Microsoft's Board, Has Advice For Nadella

Newsy (Aug. 19, 2014) In a letter to Microsoft CEO Satya Nadella, Ballmer said he's leaving the board of directors and offered tips on how the company can be successful. Video provided by Newsy
Powered by NewsLook.com
What Google Can Gain From Special Accounts For Children

What Google Can Gain From Special Accounts For Children

Newsy (Aug. 19, 2014) Google will reportedly offer official accounts for children younger than 13 years old. Video provided by Newsy
Powered by NewsLook.com
Breakingviews: Ebola's Economic Impact Could Eclipse SARS

Breakingviews: Ebola's Economic Impact Could Eclipse SARS

Reuters - Business Video Online (Aug. 18, 2014) The virus ravaging Africa has yet to spread elsewhere. Yet Asia’s SARS crisis in 2003 showed how changes to behaviour can hurt the economy more than the actual disease, says Breakingviews' Una Galani. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins