Featured Research

from universities, journals, and other organizations

New Treatment Options For Some Difficult Cancers Improve Survival And Quality Of Life

Date:
March 21, 2005
Source:
Wake Forest University Baptist Medical Center
Summary:
Researchers at Wake Forest University Baptist Medical Center have shown that surgery combined with inserting heated chemotherapy drugs directly into the abdomen can improve survival rates and quality of life in patients with several cancers that historically have a poor prognosis.

WINSTON-SALEM, N.C. – Researchers at Wake Forest University Baptist Medical Center have shown that surgery combined with inserting heated chemotherapy drugs directly into the abdomen can improve survival rates and quality of life in patients with several cancers that historically have a poor prognosis.

Results of four separate studies are being presented at the Society of Oncology Surgeons national meeting March 3-5 in Atlanta.

The types of cancer reported at the meeting that have been treated with a combination of surgery and intraperitoneal hyperthermic chemotherapy (IPHC) are tumors of the abdominal cavity that have spread from the appendix, small bowel and advanced ovarian cancer.

The technique is also useful for tumors that have spread from the colon, rectum, stomach as well as well as mesothelioma of the abdominal cavity.

Peritoneal cancer -- cancer of the lining of the abdominal wall -- is a very common cause of death in patients with cancers in the abdomen. Surgery alone has proven to have limited effectiveness, as has radiation therapy and systemic chemotherapy. These new studies show that the combination of surgery and IPHC improves overall survival and quality of life in these selected patients.

"Patients with peritoneal cancer that has spread from the small bowel represent both a unique diagnostic and treatment challenge," said Perry Shen, M.D., assistant professor of surgical oncology and lead author of one of the studies. Attempts to treat this cancer with systemic chemotherapy and conventional surgery have not been successful.

The patients in this study had a mean survival of 45.1 months, compared to 3.1 months for patients who received only traditional treatment.

"While further study is needed on the effects of surgery and IPHC with other treatments," said Shen, "the data from this study suggest that this combination seems to be an effective and attractive option in a very difficult situation."

In a study of patients with tumors in the abdominal cavity which have spread from tumors of the appendix, data from John Stewart, M.D., instructor in surgery, show that long-term survival is anticipated in the majority of patients with low grade tumors who are treated with surgery and IPHC. High grade lesions result in significantly lower survival rates even with this treatment. High grade and low grade refer to the stage of malignancy.

A study of patients with advanced ovarian cancer showed that it is responsive to a combination of surgery and IPHC. The treatment plan could also include systemic chemotherapy. Additional IPHC treatment was feasible during subsequent reassessment surgery.

"Surgery combined with IPHC seems to be a life extending and enhancing treatment option for patients with some of the most difficult cancers," said Edward Levine, MD, professor and head of surgical oncology at Wake Forest Baptist. The positive results of these studies support the need for further evaluation of the use of IPHC and surgery in the treatment of other metastatic cancers of the abdomen.


Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "New Treatment Options For Some Difficult Cancers Improve Survival And Quality Of Life." ScienceDaily. ScienceDaily, 21 March 2005. <www.sciencedaily.com/releases/2005/03/050309145839.htm>.
Wake Forest University Baptist Medical Center. (2005, March 21). New Treatment Options For Some Difficult Cancers Improve Survival And Quality Of Life. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2005/03/050309145839.htm
Wake Forest University Baptist Medical Center. "New Treatment Options For Some Difficult Cancers Improve Survival And Quality Of Life." ScienceDaily. www.sciencedaily.com/releases/2005/03/050309145839.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins